rewirebio.iobenchmarks
Evaluation

CIViC-Fact v3 post-cutoff within-linked-publication retrieval: fine-tuned MedCPT cross-encoder

Scoped author-reported evaluation on the single post-cutoff temporal cohort; read the protocol and cohort limits before comparing to any other retrieval figure.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-07-1448159e6a81 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Fine-tuned MedCPT cross-encoder (passage retrieval)Protocol: CIViC-Fact v3 within-linked-publication passage retrieval, post-cutoff cohort
Dataset: CIViC-Fact v3 post-cutoff temporal-evaluation cohort, 2026-03-03 to 2026-06-09
37/40 (92.5%) appropriate_retrieval_rate_postcutoff
percent · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC-Fact v3 post-cutoff within-linked-publication retrieval: fine-tuned MedCPT cross-encoder

Not reported

Aggregation: Not reported

CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3) · Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15): '...both the fine-tuned MedCPT model and the 8B Qwen 3 reranker performed similarly retrieving appropriate content for 37 of the remaining 40 entries (92.5%).'

Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.

Evaluation procedure

Not reported

Configuration
Fine-tuned MedCPT cross-encoder (passage retrieval)
Protocol
CIViC-Fact v3 within-linked-publication passage retrieval, post-cutoff cohort
Dataset
CIViC-Fact v3 post-cutoff temporal-evaluation cohort, 2026-03-03 to 2026-06-09
origin
Author-reported evaluation
configuration
Not reported
protocol id
ucc-clinical-egfr-protocol-civicfact-v3-retrieval
dataset version
Not reported
split
Not reported
population
40 scored post-cutoff entries (of 42 main-text-eligible, of 66 curator-evaluated, of 150 candidate CIViC entries submitted/revised 2026-03-03 to 2026-06-09)
inputs
Claim plus the single publication CIViC already links to it; top-5 retrieved passages
adaptation
Not reported
metric implementation
Manual review judgment of 'appropriate' (sufficient) retrieved content per entry; source-defined, not an automated or recomputed metric. Reviewer count, blinding and replicate/seed structure for this judgment are UNREPORTED; the source's separately described curator/group-consensus process (Methods) covers reference-label assignment for the cohort, not this retrieval judgment, and neither is assumed here.
aggregation
Not reported
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Not reported
Adaptation
Not reported
Scoring implementation
Manual review judgment of 'appropriate' (sufficient) retrieved content per entry; source-defined, not an automated or recomputed metric. Reviewer count, blinding and replicate/seed structure for this judgment are UNREPORTED; the source's separately described curator/group-consensus process (Methods) covers reference-label assignment for the cohort, not this retrieval judgment, and neither is assumed here.

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-07-1448159e6a81
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Not reported
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Not reported
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Not reported
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Claim plus the single publication CIViC already links to it; top-5 retrieved passages
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.metric_implementation
Manual review judgment of 'appropriate' (sufficient) retrieved content per entry; source-defined, not an automated or recomputed metric. Reviewer count, blinding and replicate/seed structure for this judgment are UNREPORTED; the source's separately described curator/group-consensus process (Methods) covers reference-label assignment for the cohort, not this retrieval judgment, and neither is assumed here.
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.population
40 scored post-cutoff entries (of 42 main-text-eligible, of 66 curator-evaluated, of 150 candidate CIViC entries submitted/revised 2026-03-03 to 2026-06-09)
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.protocol_id
ucc-clinical-egfr-protocol-civicfact-v3-retrieval
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.split
Not reported
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.label_reference
Manual review of retrieved passages against the claim; not independently adjudicated EGFR/NSCLC clinical ground truth. Reviewer identity/count unreported.
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.label_reference

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-10-07-1448159e6a81 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: ucc-clinical-egfr-eval-medcpt-ft-postcutoff

areas
dna-genomes
contexts
clinical_research
origin
author_reported
source locator
Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15); selection chain in Methods, 'Temporal evaluation' and Supplementary Figure 2 (printed page 33 / PDF page 34).
published score reproduction
false
review
method: automated_source_review; reviewer: Claude Sonnet EGFR-evidence-research worker; date: 2026-10-07; note: Source-backed literature curation with independent automated transcription and scope checks, independently reviewed by Codex across two review cycles before ingestion. No new model execution, independent experimental replication, qualified human scientific review or clinical validation.; source id: ucc-clinical-egfr-source-civicfact-v3
comparison
protocol id: ucc-clinical-egfr-protocol-civicfact-v3-retrieval; dataset version: Not reported; split: Not reported; population: 40 scored post-cutoff entries (of 42 main-text-eligible, of 66 curator-evaluated, of 150 candidate CIViC entries submitted/revised 2026-03-03 to 2026-06-09); inputs: Claim plus the single publication CIViC already links to it; top-5 retrieved passages; adaptation: Not reported; metric implementation: Manual review judgment of 'appropriate' (sufficient) retrieved content per entry; source-defined, not an automated or recomputed metric. Reviewer count, blinding and replicate/seed structure for this judgment are UNREPORTED; the source's separately described curator/group-consensus process (Methods) covers reference-label assignment for the cohort, not this retrieval judgment, and neither is assumed here.; aggregation: Not reported; budget: Not reported
label reference
Manual review of retrieved passages against the claim; not independently adjudicated EGFR/NSCLC clinical ground truth. Reviewer identity/count unreported.
same cohort note
Both retriever configurations (this evaluation and its counterpart) were evaluated on the identical 40-entry post-cutoff cohort; this is one temporal cohort, not two independent cohorts, and involves no new execution by Rewire.
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