rewirebio.iobenchmarks
Dataset

CIViC-Fact v3 post-cutoff temporal-evaluation cohort, 2026-03-03 to 2026-06-09

CIViC entries submitted or revised in the stated window, used to probe curation drift after the CIViC-Fact dataset's last build. Pan-cancer; not EGFR- or NSCLC-tagged. Partial coverage only: most of the original 150 candidates are excluded before scoring, by design, for full-text access, source overlap, data-quality, and evidence-sufficiency reasons.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-07-1448159e6a81 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

2 evaluations · 2 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Fine-tuned MedCPT cross-encoder (passage retrieval)Protocol: CIViC-Fact v3 within-linked-publication passage retrieval, post-cutoff cohort
Dataset: CIViC-Fact v3 post-cutoff temporal-evaluation cohort, 2026-03-03 to 2026-06-09
37/40 (92.5%) appropriate_retrieval_rate_postcutoff
percent · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC-Fact v3 post-cutoff within-linked-publication retrieval: fine-tuned MedCPT cross-encoder

Not reported

Aggregation: Not reported

CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3) · Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15): '...both the fine-tuned MedCPT model and the 8B Qwen 3 reranker performed similarly retrieving appropriate content for 37 of the remaining 40 entries (92.5%).'
Configuration: Qwen3-Reranker-8B (pretrained, not fine-tuned)Protocol: CIViC-Fact v3 within-linked-publication passage retrieval, post-cutoff cohort
Dataset: CIViC-Fact v3 post-cutoff temporal-evaluation cohort, 2026-03-03 to 2026-06-09
37/40 (92.5%) appropriate_retrieval_rate_postcutoff
percent · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC-Fact v3 post-cutoff within-linked-publication retrieval: Qwen3-Reranker-8B (pretrained)

Not reported

Aggregation: Not reported

CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3) · Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15): '...both the fine-tuned MedCPT model and the 8B Qwen 3 reranker performed similarly retrieving appropriate content for 37 of the remaining 40 entries (92.5%).'

Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-07-1448159e6a81
Property and statementOriginal source and locationReview and provenance
attributes.population.candidate_entries
150
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.candidate_entries

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.entries_curator_evaluated
66
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.entries_curator_evaluated

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.entries_maintext_eligible
42
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.entries_maintext_eligible

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.entries_scored
40
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.entries_scored

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.excluded_full_text_not_accessible
68
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.excluded_full_text_not_accessible

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.excluded_manuscript_in_train_dev_test
14
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.excluded_manuscript_in_train_dev_test

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.excluded_nei_requires_supplement_or_images
24
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.excluded_nei_requires_supplement_or_images

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.excluded_nei_substantially_revised_claim
2
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.excluded_nei_substantially_revised_claim

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.excluded_non_content_data_error
2
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.excluded_non_content_data_error

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population.note
150 - 68 - 14 - 2 = 66; 66 - 24 (NEI, supplement/image required) = 42 main-text-eligible; 42 - 2 (NEI, substantially revised claim) = 40 scored (9 + 7 + 24 = 40). Enriched cohort per source Discussion; not representative of CIViC overall. No EGFR or NSCLC subgroup is tagged anywhere in this cohort.
Context-only references
CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations (bioRxiv v3)

Original source ↗

Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).

Version: bioRxiv preprint doi:10.1101/2025.09.10.675443, Version 3, posted 2026-08-29 (per in-document header and bioRxiv API version metadata); published: NA.
Retrieved: 2026-10-07T09:28:49Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population.note

Source artifact SHA-256: 6beb79ede82f7263a06eafc844bcb4ae41538323e3c9a9a7fa5420f08a8add55

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-10-07-1448159e6a81 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: ucc-clinical-egfr-data-civicfact-v3-postcutoff

areas
dna-genomes
contexts
clinical_research
population
candidate entries: 150; window: 2026-03-03 to 2026-06-09; excluded full text not accessible: 68; excluded manuscript in train dev test: 14; excluded non content data error: 2; entries curator evaluated: 66; excluded nei requires supplement or images: 24; entries maintext eligible: 42; excluded nei substantially revised claim: 2; entries scored: 40; scored breakdown: revisions major: 9; revisions minor: 7; supports no revision: 24; note: 150 - 68 - 14 - 2 = 66; 66 - 24 (NEI, supplement/image required) = 42 main-text-eligible; 42 - 2 (NEI, substantially revised claim) = 40 scored (9 + 7 + 24 = 40). Enriched cohort per source Discussion; not representative of CIViC overall. No EGFR or NSCLC subgroup is tagged anywhere in this cohort.
source locator
Methods, 'Temporal evaluation' subsection (selection chain); Supplementary Figure 2 (printed page 33 / PDF page 34, 'Selection of CIViC entries for the post-cutoff cohort'); retrieval result reported in Results, 'Passage Retrieval Models Perform Well without Fine-Tuning' subsection (printed page 14 / PDF page 15).
review
method: automated_source_review; reviewer: Claude Sonnet EGFR-evidence-research worker; date: 2026-10-07; note: Source-backed literature curation with independent automated transcription and scope checks, independently reviewed by Codex across two review cycles before ingestion. No new model execution, independent experimental replication, qualified human scientific review or clinical validation.; source id: ucc-clinical-egfr-source-civicfact-v3
Related records

Suggest a correction