Published clinical validation; transcribed, not reproduced.
1 evaluation · 8 results. Different protocols are not a single leaderboard.
Protocol: Target-level detection of respiratory pathogens against routine multiplex PCR, validation set (Sanderson et al. 2026) · Dataset: Validation set: 344 prospectively collected nasopharyngeal swabs (Sanderson et al. 2026)
Sorted by False negatives (all PCR targets; target level; reference: routine multiplex PCR) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | False negatives (all PCR targets; target level; reference: routine multiplex PCR) | False positives (all PCR targets; target level; reference: routine multiplex PCR) | Recall (all PCR targets; target level; reference: routine multiplex PCR) | Recall (pathogen target: influenza A; target level; reference: routine multiplex PCR) | Recall (pathogen target: rhinovirus/enterovirus; target level; reference: routine multiplex PCR) | Recall (pathogen target: RSV; target level; reference: routine multiplex PCR) | Recall (pathogen target: SARS-CoV-2; target level; reference: routine multiplex PCR) | Specificity (all PCR targets; target level; reference: routine multiplex PCR) |
|---|---|---|---|---|---|---|---|---|
| Pre-specified detection criteria (Sanderson et al. 2026)Evaluation | 127 | nine | 51% | 58% | 19% | 85% | 65% | 99.8% |
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Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation Thresholds fixed on the derivation set: (genome coverage >= 1 read > 0.25% OR area under the genome > 0.003 OR reads mapping to the reference > 0.006%) AND >= 2 target reads AND ratio criterion > 0.1; super-accuracy basecalling Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation All targets in samples passing QC, or the stated subset Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget Not reported Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version Validation set, 344 nasopharyngeal swabs Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs RNA from nasopharyngeal swabs in viral transport medium Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation Target-level sensitivity and specificity against routine multiplex PCR Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population Pathogen targets in the samples passing QC Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id rna-pathogen-20261011-sanderson2026-protocol-validation Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Validation set Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Limitations1 values
| Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance', 'Performance by pathogen' and 'Performance by viral load (Cn,Ct)' Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: rna-pathogen-20261011-sanderson2026-eval-prespecified