Recall (all PCR targets; target level; reference: routine multiplex PCR) of Pre-specified detection criteria (Sanderson et al. 2026) on Validation set: 344 prospectively collected nasopharyngeal swabs (Sanderson et al. 2026)
51% Recall (all PCR targets; target level; reference: routine multiplex PCR)
Methods
- Tested configuration
- Pre-specified detection criteria (Sanderson et al. 2026)
- Protocol
- Target-level detection of respiratory pathogens against routine multiplex PCR, validation set (Sanderson et al. 2026)
- Dataset
- Validation set: 344 prospectively collected nasopharyngeal swabs (Sanderson et al. 2026)
- Procedure
- Target-level detection of respiratory pathogens against routine multiplex PCR, validation set (Sanderson et al. 2026)
- Evaluation
- Pre-specified detection criteria on the validation set (Sanderson et al. 2026)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- 95% CI 45 to 57
- Evidence
- Author-reported evaluation · source checkedClinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study · Results 'Validation Set: Diagnostic performance' paragraph 4: "133/260 (51%, 95%CI: 45-57%) PCR-positive results (i.e. gold-standard positives) were also detected by sequencing"
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Validation set
- Adaptation
- Thresholds fixed on the derivation set: (genome coverage >= 1 read > 0.25% OR area under the genome > 0.003 OR reads mapping to the reference > 0.006%) AND >= 2 target reads AND ratio criterion > 0.1; super-accuracy basecalling
- Scoring implementation
- Target-level sensitivity and specificity against routine multiplex PCR
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 51% Individual claims | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 4: "133/260 (51%, 95%CI: 45-57%) PCR-positive results (i.e. gold-standard positives) were also detected by sequencing" Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | source checked ["source-hash-verification","independent-cell-check"] · 2026-10-11 author reported Audit detailsRe-downloaded the pinned artifact and matched its SHA-256; compared every value with a separate stdlib parser written for this review (the extractor's script was not run) and checked a stratified sample by hand against the rendered table. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study · Original source · medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML
Technical metadata and extraction receipts
Stable ID: rna-pathogen-20261011-sanderson2026-result-prespecified-sensitivity
- metric
- recall
- metric direction
- higher
- unit
- percent
- printed value
- 51%
- numeric value
- 51
- metric qualifier
- all PCR targets; target level; reference: routine multiplex PCR
- source locator
- Results 'Validation Set: Diagnostic performance' paragraph 4: "133/260 (51%, 95%CI: 45-57%) PCR-positive results (i.e. gold-standard positives) were also detected by sequencing"
- numerator
- 133
- denominator
- 260
- uncertainty
- type: confidence_interval; lower: 45; upper: 57; level: 0.95; printed: 95%CI: 45-57%
- review
- method: source-hash-verification; independent-cell-check; reviewer: claude; reviewer note: Separate Claude review agent (reviewer-path), independent of the extractor; no human review claimed; date: 2026-10-11; artifact sha256: c0bc5c035742f53fe291e08b9d956102e102fd743a55de503f00bcaead36a7e2; retrieval url: https://www.medrxiv.org/content/early/2026/02/26/2026.02.06.26345651.source.xml; method note: Transcribed from the Results text of the pinned JATS XML; the extraction script asserts that the quoted string occurs in the located paragraph.; note: Re-downloaded the pinned artifact and matched its SHA-256; compared every value with a separate stdlib parser written for this review (the extractor's script was not run) and checked a stratified sample by hand against the rendered table.