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Evaluation

PhyloP 241 on ClinVar noncoding non-SNVs, intergenic (Evo 2 paper)

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 2 results. Different protocols are not a single leaderboard.

Protocol: Zero-shot ClinVar noncoding non-SNVs, intergenic classification (Evo 2 paper, Supplementary Data 1) · Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)

Sorted by AUPRC (zero-shot; ClinVar noncoding non-SNVs, intergenic) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationAUPRC (zero-shot; ClinVar noncoding non-SNVs, intergenic)AUROC (zero-shot; ClinVar noncoding non-SNVs, intergenic)
PhyloP 241 (Evo 2 paper variant effect evaluations)Evaluation0.9170.875
All 2 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: PhyloP 241 (Evo 2 paper variant effect evaluations)Protocol: Zero-shot ClinVar noncoding non-SNVs, intergenic classification (Evo 2 paper, Supplementary Data 1)
Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)
0.917 AUPRC (zero-shot; ClinVar noncoding non-SNVs, intergenic)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

PhyloP 241 on ClinVar noncoding non-SNVs, intergenic (Evo 2 paper)

gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-noncoding-non-snv-intergenic

Aggregation: Not reported

Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell J222, row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic', column 'AUPRC'
Configuration: PhyloP 241 (Evo 2 paper variant effect evaluations)Protocol: Zero-shot ClinVar noncoding non-SNVs, intergenic classification (Evo 2 paper, Supplementary Data 1)
Dataset: ClinVar October 2024 release, filtered (Brixi et al. 2026)
0.875 AUROC (zero-shot; ClinVar noncoding non-SNVs, intergenic)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

PhyloP 241 on ClinVar noncoding non-SNVs, intergenic (Evo 2 paper)

gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-noncoding-non-snv-intergenic

Aggregation: Not reported

Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026); Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026) · Supplementary Data 1 (sheet 'Sheet1') cell I222, row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic', column 'AUROC'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Zero-shot ClinVar noncoding non-SNVs, intergenic classification (Evo 2 paper, Supplementary Data 1)

Configuration
PhyloP 241 (Evo 2 paper variant effect evaluations)
Protocol
Zero-shot ClinVar noncoding non-SNVs, intergenic classification (Evo 2 paper, Supplementary Data 1)
Dataset
ClinVar October 2024 release, filtered (Brixi et al. 2026)
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-14
protocol id
gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-noncoding-non-snv-intergenic
dataset version
ClinVar October 2024 release, filtered as in SI A.3.13
split
No split; all variants in the stratum scored
population
ClinVar noncoding non-SNVs, intergenic: 4 pathogenic/likely pathogenic, 4 benign/likely benign, 8 total
inputs
PhyloP score at the variant; mean over affected reference positions for non-SNVs (SI A.3.12)
adaptation
zero-shot
metric implementation
Not reported
aggregation
Not reported
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
No split; all variants in the stratum scored
Adaptation
zero-shot
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

54 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
zero-shot
Context-only references
evo2: Journal full-text XML

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T20:16:14.422554+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Comparison: adaptation
zero-shot
Context-only references
Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026)

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx
Retrieved: 2026-10-14T12:01:04Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: adaptation
zero-shot
Context-only references
Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026)

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
Retrieved: 2026-10-14T12:01:04Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
evo2: Journal full-text XML

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T20:16:14.422554+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026)

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx
Retrieved: 2026-10-14T12:01:04Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026)

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
Retrieved: 2026-10-14T12:01:04Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
evo2: Journal full-text XML

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T20:16:14.422554+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Comparison: budget
Not reported
Context-only references
Genome modelling and design across all domains of life with Evo 2: Supplementary Data 1, human variant effect prediction results (Nature 2026)

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 652 (2026), published 2026-03-04; Supplementary Data 1 file 41586_2026_10176_MOESM3_ESM.xlsx
Retrieved: 2026-10-14T12:01:04Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 159f321775d634d9ed53b7a81c5cc1b5ef3d407880997e0f8c69bb8315a20a51

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
Genome modelling and design across all domains of life with Evo 2: Supplementary Information (Nature 2026)

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 652 (2026), published 2026-03-04; Supplementary Information file 41586_2026_10176_MOESM1_ESM.pdf (73 pages)
Retrieved: 2026-10-14T12:01:04Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: fe2a99108a4ce5c0f4ef1595605eaec709fa86204410d5b66c1384327eb7b925

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: dataset version
ClinVar October 2024 release, filtered as in SI A.3.13
Context-only references
evo2: Journal full-text XML

Original source ↗

Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T20:16:14.422554+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: d043dbda49e023ef6b70e36e7ca7832bda6b7af6c5934368e8778a7f23cda8bd

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

3 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: gfm-guides-20261014-evo2-brixi2026-eval-phylop-241-clinvar-noncoding-non-snv-intergenic

areas
dna-genomes
contexts
research
origin
author_reported
protocol
gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-noncoding-non-snv-intergenic
version
Primary source as retrieved 2026-10-14
comparison
protocol id: gfm-guides-20261014-evo2-brixi2026-protocol-clinvar-noncoding-non-snv-intergenic; dataset version: ClinVar October 2024 release, filtered as in SI A.3.13; split: No split; all variants in the stratum scored; population: ClinVar noncoding non-SNVs, intergenic: 4 pathogenic/likely pathogenic, 4 benign/likely benign, 8 total; inputs: PhyloP score at the variant; mean over affected reference positions for non-SNVs (SI A.3.12); adaptation: zero-shot; metric implementation: Not reported; aggregation: Not reported; budget: Not reported
source locator
Supplementary Data 1 (sheet 'Sheet1') row 222: Model 'PhyloP 241', Data 'ClinVar', Genomic_Feature 'Noncoding', Variant_Type 'non-SNV', Sub_category 'Intergenic'
missing metadata
comparison.aggregation: reason: unreported; comparison.budget: reason: unreported; comparison.metric implementation: reason: unreported
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