| Configuration: AVI six-model ensemble (AlphaGenome Atlas v1) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0.283 AUPRC (AVI baseline row, TraitGym Complex column) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI AVI Model (Baseline) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Baseline', row 'AVI Model', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'All except AlphaGenome' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -27.7% AUPRC relative difference (ablation 'All except AlphaGenome' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI All except AlphaGenome (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'All except AlphaGenome', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'AlphaGenome' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -17.3% AUPRC relative difference (ablation 'AlphaGenome' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI AlphaGenome (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'AlphaMissense' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0.67% AUPRC relative difference (ablation 'AlphaMissense' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI AlphaMissense (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'AlphaMissense', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'Cactus' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -6.64% AUPRC relative difference (ablation 'Cactus' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI Cactus (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'Cactus', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'Consequence' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0.28% AUPRC relative difference (ablation 'Consequence' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI Consequence (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'Consequence', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'Conservation' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -26.3% AUPRC relative difference (ablation 'Conservation' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI Conservation (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'Conservation', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'Indel Type' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -2.19% AUPRC relative difference (ablation 'Indel Type' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI Indel Type (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'Indel Type', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'PhastCons' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -2.15% AUPRC relative difference (ablation 'PhastCons' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI PhastCons (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'PhastCons', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'Protein' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 1.13% AUPRC relative difference (ablation 'Protein' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI Protein (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'Protein', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'Splicing Removed Only' (Retrained, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | -2.61% AUPRC relative difference (ablation 'Splicing Removed Only' (Retrained) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI Splicing Removed Only (Retrained) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'Splicing Removed Only', column 'TraitGym Complex' |
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| Configuration: AVI ablation '+ No Indel Type' (Features Set to Zero, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0% AUPRC relative difference (ablation '+ No Indel Type (second occurrence, below 'No AlphaMissense Indel Features')' (Features Set to Zero) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI + No Indel Type (Features Set to Zero) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Features Set to Zero', row '+ No Indel Type (second occurrence, below 'No AlphaMissense Indel Features')', column 'TraitGym Complex' |
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| Configuration: AVI ablation 'No AlphaMissense Indel Features' (Features Set to Zero, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0% AUPRC relative difference (ablation 'No AlphaMissense Indel Features' (Features Set to Zero) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI No AlphaMissense Indel Features (Features Set to Zero) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Features Set to Zero', row 'No AlphaMissense Indel Features', column 'TraitGym Complex' |
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| Configuration: AVI ablation '+ No Indel Type' (Features Set to Zero, AlphaGenome Atlas Table S2) | Protocol: AVI feature ablation, TraitGym Complex column, AUPRC (AlphaGenome Atlas Table S2) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0% AUPRC relative difference (ablation '+ No Indel Type' (Features Set to Zero) relative to the AVI baseline row, TraitGym Complex column) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAVI + No Indel Type (Features Set to Zero) on TraitGym Complex (AlphaGenome Atlas Table S2) ag-atlas-20261019-protocol-table-s2-traitgym-complex Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Features Set to Zero', row '+ No Indel Type', column 'TraitGym Complex' |
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| Configuration: AVI six-model ensemble (AlphaGenome Atlas v1) | Protocol: TraitGym fine-mapped GWAS variants, AUPRC after AVI filtering (AlphaGenome Atlas) Dataset subset: TraitGym Complex traits after AVI positional filtering (AlphaGenome Atlas) | 0.28 AUPRC (TraitGym fine-mapped GWAS (Complex)) unitless · higher Uncertainty: Not reported by the source: Fig. 2B draws 95% bootstrap intervals (100 bootstraps) without printing them. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceavi on TraitGym fine-mapped GWAS (Complex) (AlphaGenome Atlas Fig. 2B) ag-atlas-20261019-protocol-traitgym-complex-auprc Aggregation: Not reported AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Results 'State-of-the-art interpretable genome-wide variant prioritization with AVI' paragraph 1 (page 5), citing Fig. 2B: 'TraitGym Complex, AUPRC 0.28 vs. 0.27' |
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