AVI ablation 'No AlphaMissense Indel Features' (Features Set to Zero, AlphaGenome Atlas Table S2)
Frozen AVI ensemble without the inference-time AlphaMissense imputation for indels.
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Evaluations and results
5 evaluations · 5 results. Different protocols are not a single leaderboard.
Sorted by AUPRC relative difference (ablation 'No AlphaMissense Indel Features' (Features Set to Zero) relative to the AVI baseline row, ClinVar column) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
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Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.
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How it works, versions and access
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Evidence
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Evidence table
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Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
1 source record and release history
- AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Original source · medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Technical metadata and extraction receipts
Stable ID: ag-atlas-20261019-config-avi-ablation-zero-alphamissense-indel
- areas
- dna-genomes
- contexts
- research
- method types
- supervised_machine_learning
- reported name
- No AlphaMissense Indel Features
- parameters
- Table S2 section 'Features Set to Zero', row 'No AlphaMissense Indel Features'. Inference-time zeroing on the frozen AVI ensemble; '+' applies 'No Indel Type' to the row above.
- source locator
- Table S2 and caption (page 70); Methods 'Feature Ablations' (page 27)
Related records
- configuration of: AlphaGenome Variant Impact (AVI)
- system: AVI No AlphaMissense Indel Features (Features Set to Zero) on ClinVar (AlphaGenome Atlas Table S2)
- system: AVI No AlphaMissense Indel Features (Features Set to Zero) on ncVar (AlphaGenome Atlas Table S2)
- system: AVI No AlphaMissense Indel Features (Features Set to Zero) on SGE (AlphaGenome Atlas Table S2)
- system: AVI No AlphaMissense Indel Features (Features Set to Zero) on TraitGym Complex (AlphaGenome Atlas Table S2)
- system: AVI No AlphaMissense Indel Features (Features Set to Zero) on TraitGym Mendelian (AlphaGenome Atlas Table S2)