rewirebio.iobenchmarks
Dataset

Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)

88 clinical metagenomic datasets with 1144 PCR results as reference.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-09-ba02f2f4a36e · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

60 evaluations · 660 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.941 auroc
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell D19, row 'Centrifuge', column 'AUC'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
35.5 regression-intercept
unitless · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell J19, row 'Centrifuge', column 'LR intercept'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
34.8% pearson-r-squared
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell K19, row 'Centrifuge', column 'LR r2, %'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
-1.97 regression-slope
unitless · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell I19, row 'Centrifuge', column 'LR slope'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.941 auroc
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell D29, row 'Centrifuge', column 'AUC'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
27.3 regression-intercept
unitless · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell J29, row 'Centrifuge', column 'LR intercept'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
40.2% pearson-r-squared
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell K29, row 'Centrifuge', column 'LR r2, %'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
-2.17 regression-slope
unitless · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell I29, row 'Centrifuge', column 'LR slope'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.999 negative-predictive-value
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell H29, row 'Centrifuge', column 'NPV (ROC)'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.354 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell G29, row 'Centrifuge', column 'PPV (ROC)'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.0688 roc-distance
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell C29, row 'Centrifuge', column 'Informedness'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.958 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell E29, row 'Centrifuge', column 'SN (ROC)'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.945 specificity
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell F29, row 'Centrifuge', column 'SL (ROC)'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
5 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell L29, row 'Centrifuge', column 'Taxa'
Configuration: Centrifuge, human reads removed, and assigned read counts normalised by target genome length (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
5 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed, and assigned read counts normalised by target genome length: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads and normalized', cell M29, row 'Centrifuge', column 'Taxa with reads >0'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.999 negative-predictive-value
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell H19, row 'Centrifuge', column 'NPV (ROC)'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.354 precision
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell G19, row 'Centrifuge', column 'PPV (ROC)'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.0688 roc-distance
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell C19, row 'Centrifuge', column 'Informedness'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.958 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell E19, row 'Centrifuge', column 'SN (ROC)'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.945 specificity
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell F19, row 'Centrifuge', column 'SL (ROC)'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
5 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell L19, row 'Centrifuge', column 'Taxa'
Configuration: Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
5 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, human reads removed (Bowtie2 to GRCh38) before classification: family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'excl. human reads', cell M19, row 'Centrifuge', column 'Taxa with reads >0'
Configuration: Centrifuge, all trimmed reads (human reads included) (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
0.969 auroc
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell D8, row 'Centrifuge', column 'AUC'
Configuration: Centrifuge, all trimmed reads (human reads included) (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
38.8 regression-intercept
unitless · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell J8, row 'Centrifuge', column 'LR intercept'
Configuration: Centrifuge, all trimmed reads (human reads included) (Carbo et al. 2022)Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1)
Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
50.5% pearson-r-squared
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Centrifuge, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022)

rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0

Aggregation: Not reported

Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell K8, row 'Centrifuge', column 'LR r2, %'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

9 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statementOriginal source and locationReview and provenance
attributes.accession
NCBI SRA SRX6713943-SRX6714030
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.accession

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.assay
EAV and PhHV-1 internal controls; MagNAPure 96 total nucleic acid extraction; NEBNext Ultra II Directional RNA library with a protocol for RNA and DNA in one tube; NextSeq 500, about 10 million 150 bp paired-end reads per sample
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.assay

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.denominator
1144
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.denominator

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population
88 nasal washings from 63 patients with COPD suspected of respiratory infection; 13 respiratory virus PCR targets per sample, 24 positive and 1120 negative PCR results. All targets are RNA viruses (rhinovirus/enterovirus, parainfluenza 1-4, influenza A and B, coronaviruses NL63, 229E, HKU1/OC43, metapneumovirus, RSV).
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.source_locator
Sections 2.1-2.2; Table 1; Data Availability Statement
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.split
No split; whole cohort
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.split

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.version
As described in Carbo et al. 2022 (NCBI SRA SRX6713943-SRX6714030, human reads removed)
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.version

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

description
88 clinical metagenomic datasets with 1144 PCR results as reference.
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

name
Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)
Context-only references
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort

Original source ↗

Sections 2.1-2.2; Table 1; Data Availability Statement

Version: Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Retrieved: 2026-10-09T20:06:32Z

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: e6683855ad278a555598295fdc4166e54ddb0e39e3d971878b898b20bc8ddf95

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

1 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: rna-pathogen-20261009-data-carbo2022-copd-nasal-washes

areas
microbes-communities
contexts
clinical_research
version
As described in Carbo et al. 2022 (NCBI SRA SRX6713943-SRX6714030, human reads removed)
accession
NCBI SRA SRX6713943-SRX6714030
population
88 nasal washings from 63 patients with COPD suspected of respiratory infection; 13 respiratory virus PCR targets per sample, 24 positive and 1120 negative PCR results. All targets are RNA viruses (rhinovirus/enterovirus, parainfluenza 1-4, influenza A and B, coronaviruses NL63, 229E, HKU1/OC43, metapneumovirus, RSV).
assay
EAV and PhHV-1 internal controls; MagNAPure 96 total nucleic acid extraction; NEBNext Ultra II Directional RNA library with a protocol for RNA and DNA in one tube; NextSeq 500, about 10 million 150 bp paired-end reads per sample
split
No split; whole cohort
denominator
1144
source locator
Sections 2.1-2.2; Table 1; Data Availability Statement
Related records

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