Absolute Spearman correlation edges (Kendiukhov 2026)
Absolute Spearman correlation between the perturbed gene and each other gene across the same control cells used for attention extraction.
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Evaluations and results
5 evaluations · 5 results. Different protocols are not a single leaderboard.
Sorted by AUROC (per-perturbation AUROC for DE targets (LFC > 0.5), summarised over perturbations; K562 CRISPRi) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
All 5 result rows with coverage, uncertainty and sources
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How it works, versions and access
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Evidence
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Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
1 source record and release history
- Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) · Original source · Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14)
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-kendiukhov2026-config-spearman-edge
- areas
- single-cell; biological-networks
- contexts
- research
- method types
- conventional_pipeline
- reported name
- correlation
- foundation model eligible
- false
- representation
- Absolute Spearman correlation between the perturbed gene and each other gene across the same control cells used for attention extraction.
- source locator
- Page 13 'Models and data', 'Attention extraction and edge score computation', 'Model coverage by analysis family'
- training setting
- Computed from each dataset's control cells
- access reuse
- Analysis code github.com/Biodyn-AI/biomechinterp-framework and Zenodo 10.5281/zenodo.18701417; not pinned to a commit in the article
- missing metadata
- version: reason: inapplicable; note: Defined in the article
Related records
- configuration of: Absolute Spearman correlation edge score
- system: Absolute Spearman correlation edges on K562 CRISPRa, 77 perturbations
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- system: Absolute Spearman correlation edges on Replogle genome-scale CRISPRi, RPE1, 1,167 perturbations, confound battery
- system: Absolute Spearman correlation edges on Replogle genome-scale CRISPRi, RPE1, 1,251 evaluable perturbations
- system: Absolute Spearman correlation edges on Replogle CRISPRi RPE1, propensity-matched pairs