Configuration

CelFiE (Sun et al. 2024 benchmark)

Configuration as run in the cited comparison.

Overview

Configuration as run in the cited comparison.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

2 evaluations · 6 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: CelFiE (Sun et al. 2024 benchmark)	Protocol: Sun et al. 2024 five-cancer detection from deconvolved plasma cfMethyl-Seq (ROC-AUC per cancer type) Dataset: Plasma cfMethyl-Seq, 225 cancer patients and 193 healthy individuals (EGAD00001009003)	0.91 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CelFiE deconvolution, disease detection AUC (cfMethyl-Seq cohort) ctdnameth-20261009-protocol-sun2024-cfmethyl-detection-auc Aggregation: Not reported Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', J6; row 'Colon cancer'; column 'CelFiE' under 'AUC values'
Configuration: CelFiE (Sun et al. 2024 benchmark)	Protocol: Sun et al. 2024 five-cancer detection from deconvolved plasma cfMethyl-Seq (ROC-AUC per cancer type) Dataset: Plasma cfMethyl-Seq, 225 cancer patients and 193 healthy individuals (EGAD00001009003)	0.93 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CelFiE deconvolution, disease detection AUC (cfMethyl-Seq cohort) ctdnameth-20261009-protocol-sun2024-cfmethyl-detection-auc Aggregation: Not reported Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', J9; row 'Gastric cancer'; column 'CelFiE' under 'AUC values'
Configuration: CelFiE (Sun et al. 2024 benchmark)	Protocol: Sun et al. 2024 five-cancer detection from deconvolved plasma cfMethyl-Seq (ROC-AUC per cancer type) Dataset: Plasma cfMethyl-Seq, 225 cancer patients and 193 healthy individuals (EGAD00001009003)	0.82 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CelFiE deconvolution, disease detection AUC (cfMethyl-Seq cohort) ctdnameth-20261009-protocol-sun2024-cfmethyl-detection-auc Aggregation: Not reported Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', J5; row 'Liver cancer (cfMethyl-Seq)'; column 'CelFiE' under 'AUC values'
Configuration: CelFiE (Sun et al. 2024 benchmark)	Protocol: Sun et al. 2024 five-cancer detection from deconvolved plasma cfMethyl-Seq (ROC-AUC per cancer type) Dataset: Plasma cfMethyl-Seq, 225 cancer patients and 193 healthy individuals (EGAD00001009003)	0.83 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CelFiE deconvolution, disease detection AUC (cfMethyl-Seq cohort) ctdnameth-20261009-protocol-sun2024-cfmethyl-detection-auc Aggregation: Not reported Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', J7; row 'LUAD'; column 'CelFiE' under 'AUC values'
Configuration: CelFiE (Sun et al. 2024 benchmark)	Protocol: Sun et al. 2024 five-cancer detection from deconvolved plasma cfMethyl-Seq (ROC-AUC per cancer type) Dataset: Plasma cfMethyl-Seq, 225 cancer patients and 193 healthy individuals (EGAD00001009003)	0.83 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CelFiE deconvolution, disease detection AUC (cfMethyl-Seq cohort) ctdnameth-20261009-protocol-sun2024-cfmethyl-detection-auc Aggregation: Not reported Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', J8; row 'LUSC'; column 'CelFiE' under 'AUC values'
Configuration: CelFiE (Sun et al. 2024 benchmark)	Protocol: Sun et al. 2024 liver cancer detection from deconvolved plasma WGBS (ROC-AUC) Dataset: Plasma cfDNA WGBS, 24 liver cancer patients and 32 healthy individuals (EGAD00001000856)	0.93 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CelFiE deconvolution, disease detection AUC (liver cancer WGBS) ctdnameth-20261009-protocol-sun2024-hcc-wgbs-detection-auc Aggregation: Not reported Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', J4; row 'Liver cancer (WGBS)'; column 'CelFiE' under 'AUC values'

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Release 2026-10-09-ba02f2f4a36e · Record review: source checked

2 source records and release history

Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA · Original source · Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
Sun et al. 2024, Additional file 1 (Tables S1-S8) · Original source · Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318

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Technical metadata and extraction receipts

Stable ID: ctdnameth-20261009-config-sun2024-celfie

areas: dna-genomes
contexts: clinical_research
method types: specialist
reported name: CelFiE
foundation model eligible: false
source locator: Additional file 1 Table S7 header; Methods 'Implementation of each cfDNA deconvolution method' (P33)
missing metadata: version: reason: unreported; note: Only GitHub repository URLs are given, without a release or commit
parameters: Run with --unknowns 0 unless stated otherwise (Methods P33).

Related records

configuration of: CelFiE
system: CelFiE deconvolution, disease detection AUC (cfMethyl-Seq cohort)
system: CelFiE deconvolution, disease detection AUC (liver cancer WGBS)

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