Evidence claim

Relevance of Runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines (Hu et al. 2026) to "Select an execution workflow for large-scale diagnostic genomics"

Use case: Select an execution workflow for large-scale diagnostic genomics
Assessed by: FASTQ-to-VCF runtime, core-hours and Azure cost of three Sentieon DNAscope pipelines on one 120-vCPU instance (Hu et al. 2026 Table 2)
Relevance: Proxy evidence
Endpoint: Stage runtimes, total runtime, core-hours and Azure on-demand and spot cost for DNAscope Hybrid (10x PacBio plus 35x Illumina), DNAscope LongRead (30x PacBio) and DNAscope (30x Illumina) on one 120-vCPU instance

Gives per-genome runtime, CPU time and cloud cost for CPU-only long-read and hybrid germline pipelines on stated hardware, which no previously linked source covers. Proxy: vendor-reported values with an unstated number of runs, an unnamed sample, different inputs per pipeline, no stated software version and no licence cost.

3 reviewed evaluations

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Citation locations 1 values source id model-execution-20261011-source-hu2026-dnascope-hybrid locator Results 'Compute resource benchmark'; Table 2; Conflict of interest Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison group hu2026-dnascope-azure Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_group` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison title Sentieon DNAscope pipelines on one Azure instance (Hu et al. 2026) Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_title` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Constraints 3 values Inspect every linked evaluation's source locator before citing a result. Do not combine this mapping's evaluations with any other protocol's results; hardware, inputs, software versions and timing boundaries differ between sources. Do not read the three columns as a ranking: each pipeline has different input data. Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Endpoint Stage runtimes, total runtime, core-hours and Azure on-demand and spot cost for DNAscope Hybrid (10x PacBio plus 35x Illumina), DNAscope LongRead (30x PacBio) and DNAscope (30x Illumina) on one 120-vCPU instance Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Claimed field links:assessed_by:model-execution-20261011-protocol-hu2026-dnascope-azure-compute Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Headline metric runtime Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.headline_metric` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Limitations 6 values Author-reported by the software vendor: all authors were employed by Sentieon Inc. The three pipelines run on different inputs (hybrid, long-read and short-read data at different depths), so the table is not a like-for-like comparison. The sample behind Table 2 is not named; the study's data are GIAB HG002 to HG004 (PacBio Revio and precisionFDA Truth Challenge V2 Illumina). One value per pipeline is printed; the number of runs behind it is not stated and no spread is printed. The Sentieon software version is not stated for Table 2. Costs are Azure on-demand and spot prices and exclude the Sentieon licence. The LongRead and short-read runtimes were previously published in a Microsoft blog post (Results 'Compute resource benchmark'). Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.limitations` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Pinned records 27 values record id model-execution-20261011-eval-hu2026-dnascope-hybrid-azure fields status links attributes.origin attributes.comparison sha256 7e5d4612c9ea9f8862545d1ecd3709bdf1052854433c11ae931e5e0708eff0e6 record id model-execution-20261011-eval-hu2026-dnascope-longread-pb-azure fields status links attributes.origin attributes.comparison sha256 173928fe917e364fa230788c70a9e1d68f3bad2158643d85c334c38d723d9142 record id model-execution-20261011-eval-hu2026-dnascope-short-read-azure fields status links attributes.origin attributes.comparison sha256 831efd7db73625632c0b9a248c7ee5af64ca8c75d152dd52c2d3b7f671529431 record id model-execution-20261011-protocol-hu2026-dnascope-azure-compute fields status name description facets source_ids links attributes sha256 4955dbe735ef0f150d03bfabd255b38094342bd7d47da85826d85d43820fd291 record id model-execution-20261011-result-hu2026-dnascope-hybrid-alignment fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 a7cc0f34c9e2ce38f730c3cc7b40d266dbd7527baab060a7ed02a5002d610f6e record id model-execution-20261011-result-hu2026-dnascope-hybrid-core-hours fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 0f81ce0ef590f99b706d1bdabb132a1f29aebb87dbe9df68327739db9460c219 record id model-execution-20261011-result-hu2026-dnascope-hybrid-on-demand-cost fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 cb51d50aff3de81b67f204fa717f2ce2ec23565d111262aea4e745cdc1279fe3 record id model-execution-20261011-result-hu2026-dnascope-hybrid-preprocessing fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e785a0b08b6ab5a7d192b2d1748635a7f37ef8bca65f23e86c8f2128744f397a record id model-execution-20261011-result-hu2026-dnascope-hybrid-spot-cost fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 7b2c116d0a3e58a59806f695edaea23181e89ab28568504525aa6d2df2ba8acc record id model-execution-20261011-result-hu2026-dnascope-hybrid-total-runtime fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 1cc6b0f83face5b1230afc38405106a7ceae51c109dc72537e88c0bb5753b606 record id model-execution-20261011-result-hu2026-dnascope-hybrid-variant-calling fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 34dc883ac5fab3ca7fc317dc07d124fb7fda15f01eefd337297a183aed9e5d65 record id model-execution-20261011-result-hu2026-dnascope-longread-pb-alignment fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 8067fb5148142f81d813dea4026cdc4f31e877628216c7f633e7fc2cea8b2ce2 record id model-execution-20261011-result-hu2026-dnascope-longread-pb-core-hours fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 70f6ddb2204864684515296f52db5ae4cfc9397f0bf59b5b9b0d47059745eb30 record id model-execution-20261011-result-hu2026-dnascope-longread-pb-on-demand-cost fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 f4b4cdcfac881a7a0a2350a431ccb445f90e58e767e698b74b0c5f9f832f92db record id model-execution-20261011-result-hu2026-dnascope-longread-pb-preprocessing fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dcf56aec2c9a950398b5802f03e9a98469fd78c6e0cb174fc72388bafef56403 record id model-execution-20261011-result-hu2026-dnascope-longread-pb-spot-cost fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 6b779d79f787622896145671f95624e23d76da46e570b42c7ae5e8100178ca00 record id model-execution-20261011-result-hu2026-dnascope-longread-pb-total-runtime fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b14426f7860f152bd63ab7af13789c31069a02b08c13b9d60b65c70743cd374d record id model-execution-20261011-result-hu2026-dnascope-longread-pb-variant-calling fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 470ce3037496e916672164adfe801df97caf6171b21d329144678133cb6ffa8f record id model-execution-20261011-result-hu2026-dnascope-short-read-alignment fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e4d3ca086f5d9892050aa155fd825f1f94e90e8de197f1e19cb9bda67b4a32b4 record id model-execution-20261011-result-hu2026-dnascope-short-read-core-hours fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dc861ddb8f70e993f4b6d4705414dda55658767acf1c7eb47fcc7089dd2c2e95 record id model-execution-20261011-result-hu2026-dnascope-short-read-on-demand-cost fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b2d137136da34c52c3a68d03dc2a9a21df2c93ca6d5191d9a789f21e33568de5 record id model-execution-20261011-result-hu2026-dnascope-short-read-preprocessing fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 5635e4493d0f4ecba7ad1e6fb61a42def74f1bb00acda43bc406b7e5d024e82c record id model-execution-20261011-result-hu2026-dnascope-short-read-spot-cost fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 a73331d8e58e0a56ac63a753b4fddd9be730473bd822eaa666ccf607ff3be3cc record id model-execution-20261011-result-hu2026-dnascope-short-read-total-runtime fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 ab11a252176d62e228a86a28da47ade7f1770da3d04ca4d7f671acee16990166 record id model-execution-20261011-result-hu2026-dnascope-short-read-variant-calling fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 87fb34818f77409fa52e66e740b01a728efbd17721ea6d5a855c5d480db5abf5 record id model-execution-20261011-source-hu2026-dnascope-hybrid fields status attributes.artifact_sha256 sha256 4b9d6a0e4e509d50f13f8dfcef21c0b2eddf0c58e4a497c8188126cb6245dfed record id use-case-diagnostic-genomics-model-execution fields status name description facets attributes.question attributes.decision attributes.inputs attributes.output attributes.exclusions attributes.setting attributes.clinical_scope attributes.intended_users sha256 1c2a12431556cc6581f5aab019cf91576d2393387b88a8a2bea35ea2a3ee4a70 Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.pins` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Rationale Gives per-genome runtime, CPU time and cloud cost for CPU-only long-read and hybrid germline pipelines on stated hardware, which no previously linked source covers. Proxy: vendor-reported values with an unstated number of runs, an unnamed sample, different inputs per pipeline, no stated software version and no licence cost. Context-only references	A novel and accelerated method for integrated alignment and variant calling from short and long reads Original source ↗ model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest Version: Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML Retrieved: 2026-10-11T21:42:46Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.rationale` Source artifact SHA-256: `b138dd8976f01b4ff50f72669dea3a7062f564a9cb359417aad0dc72a8b6c859` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

A novel and accelerated method for integrated alignment and variant calling from short and long reads · Original source · Frontiers in Bioinformatics 5:1691056, published 2026-01-05; PMC12813096 full-text XML

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Technical metadata and extraction receipts

Stable ID: use-case-mapping-model-execution-20261011-hu2026-dnascope-azure-compute

field: links:assessed_by:model-execution-20261011-protocol-hu2026-dnascope-azure-compute
value: model-execution-20261011-protocol-hu2026-dnascope-azure-compute
relevance: proxy
endpoint: Stage runtimes, total runtime, core-hours and Azure on-demand and spot cost for DNAscope Hybrid (10x PacBio plus 35x Illumina), DNAscope LongRead (30x PacBio) and DNAscope (30x Illumina) on one 120-vCPU instance
rationale: Gives per-genome runtime, CPU time and cloud cost for CPU-only long-read and hybrid germline pipelines on stated hardware, which no previously linked source covers. Proxy: vendor-reported values with an unstated number of runs, an unnamed sample, different inputs per pipeline, no stated software version and no licence cost.
constraints: Inspect every linked evaluation's source locator before citing a result.; Do not combine this mapping's evaluations with any other protocol's results; hardware, inputs, software versions and timing boundaries differ between sources.; Do not read the three columns as a ranking: each pipeline has different input data.
limitations: Author-reported by the software vendor: all authors were employed by Sentieon Inc.; The three pipelines run on different inputs (hybrid, long-read and short-read data at different depths), so the table is not a like-for-like comparison.; The sample behind Table 2 is not named; the study's data are GIAB HG002 to HG004 (PacBio Revio and precisionFDA Truth Challenge V2 Illumina).; One value per pipeline is printed; the number of runs behind it is not stated and no spread is printed. The Sentieon software version is not stated for Table 2.; Costs are Azure on-demand and spot prices and exclude the Sentieon licence.; The LongRead and short-read runtimes were previously published in a Microsoft blog post (Results 'Compute resource benchmark').
revision: 1
reason: Add primary-source execution evidence from the diagnostic genomics execution literature pass (2026-10-11).
citation locators: source id: model-execution-20261011-source-hu2026-dnascope-hybrid; locator: Results 'Compute resource benchmark'; Table 2; Conflict of interest
source locator: model-execution-20261011-source-hu2026-dnascope-hybrid: Results 'Compute resource benchmark'; Table 2; Conflict of interest
comparison group: hu2026-dnascope-azure
comparison title: Sentieon DNAscope pipelines on one Azure instance (Hu et al. 2026)
headline metric: runtime
review: method: source-hash-verification; independent-cell-check; scope-review; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent uc-execution extracted and drafted; Claude (Opus 5.5) review agent reviewer-exec checked every value and this judgement against the pinned sources; reviewed at: 2026-10-12T07:50:32Z; note: Bounded primary-source transcription with independent cell check and relevance review. No execution, reproduction, qualified human scientific review or clinical validation.
reviewed evaluations: model-execution-20261011-eval-hu2026-dnascope-hybrid-azure; model-execution-20261011-eval-hu2026-dnascope-longread-pb-azure; model-execution-20261011-eval-hu2026-dnascope-short-read-azure
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