Cancer Immunotherapy Data Science Challenge

Overview

Source study/challenge grouping of the exact imported protocols. No claim that this intake implements or reproduces an executable benchmark.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

54 recorded evaluations, 54 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

54 evaluations · 54 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: CPPC submitted-method nomination campaign	Protocol: CPPC prospective nomination of desired T-cell states Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	two named-desired-state-hits targets · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc nominated target outcome Not reported Aggregation: Not reported Cancer Immunotherapy Data Science Challenge · Abstract; Results Figure 5: Dimt1 and Ndufv2 exceed Screen-1 targets on ICB objective
Configuration: CPPC original submission row 10 (unnamed method)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.799 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 10 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C10; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 11 (unnamed method)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.799 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 11 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C11; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 12 (5Features)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.813 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 12 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C12; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 13 (unnamed method)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.815 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 13 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C13; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 14 (unnamed method)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.82 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 14 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C14; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 15 (unnamed method)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.829 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 15 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C15; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 16 (scETM)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.849 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 16 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C16; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 17 (scTenifoldNet)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.859 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 17 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C17; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 18 (GO_knn)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.901 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 18 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C18; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 19 (LowExp)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.913 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 19 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C19; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 2 (PPI_Weighted)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.714 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 2 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C2; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 20 (unnamed method)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.92 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 20 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C20; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 21 (interv)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	1.27 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 21 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C21; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 3 (GWPS_K562 (H2M))	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.75 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 3 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C3; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 4 (14Features)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.764 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 4 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C4; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 5 (scBERT)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.767 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 5 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C5; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 6 (scVI)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.779 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 6 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C6; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 7 (Expression_Conditioned)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.788 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 7 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C7; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 8 (Exon)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.789 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 8 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C8; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 9 (Gene2Vec)	Protocol: CPPC original Challenge 1 final four-knockout prediction score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.79 mean-summed-cell-state-l1 summed absolute proportion error · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 c row 9 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell C9; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 11 (unnamed method)	Protocol: CPPC original Challenge 2 prospective target ranking score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.502 robust-topk-overlap-auc score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 d row 11 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell D11; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 12 (5Features)	Protocol: CPPC original Challenge 2 prospective target ranking score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.542 robust-topk-overlap-auc score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 d row 12 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell D12; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 13 (unnamed method)	Protocol: CPPC original Challenge 2 prospective target ranking score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.532 robust-topk-overlap-auc score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 d row 13 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell D13; raw XLSX numeric value (not rounded display)
Configuration: CPPC original submission row 14 (unnamed method)	Protocol: CPPC original Challenge 2 prospective target ranking score Dataset: CPPC B16-OVA mouse melanoma T-cell perturbation screens	0.547 robust-topk-overlap-auc score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source cppc table s2 d row 14 Not reported Aggregation: Not reported CPPC Table S2 original and reimplemented submission comparisons · Supplementary Table S2; media-3.xlsx sheet 'Challenge 1 & 2'; cell D14; raw XLSX numeric value (not rounded display)

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Evaluation design

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Protocols

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Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 10 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

Baseline status by linked protocol

CPPC original Challenge 1 final four-knockout prediction score · 0/2 roles measured
CPPC original Challenge 2 prospective target ranking score · 0/2 roles measured
CPPC reimplemented best-model Challenge 2 score · 0/2 roles measured
CPPC prospective nomination of desired T-cell states · 0/2 roles measured
CPPC screen-1 held-out knockout cell-state proportions · 0/2 roles measured

Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums

Coverage is derived from release 2026-09-30-e37e3ab1284d. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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Evidence

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Evidence table

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Sources and history

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Release 2026-09-30-e37e3ab1284d · Record review: source checked

3 source records and release history

Cancer Immunotherapy Data Science Challenge · Original source · 10.64898/2026.05.21.726863v1; 2026 preprint
Cancer Immunotherapy Data Science Challenge official code · Original source · 283328a9b8afc6e882eeb503ac4710bbe9f37371
CPPC Table S2 original and reimplemented submission comparisons · Original source · Table S2 media-3.xlsx, 10.64898/2026.05.21.726863v1

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Technical metadata and extraction receipts

Stable ID: ucc-research-benchmark-cppc

entity level: challenge
review: method: automated_source_review; actor: Codex research coverage worker; reviewed at: 2026-09-30T21:43:56Z; note: Primary-source table transcription and scope review; no independent reproduction or human scientific review.
source locator: Challenge setup and results; Supplementary Table S2

Related records

part of: CPPC original Challenge 1 final four-knockout prediction score
part of: CPPC original Challenge 2 prospective target ranking score
part of: CPPC reimplemented best-model Challenge 2 score
part of: CPPC prospective nomination of desired T-cell states
part of: CPPC screen-1 held-out knockout cell-state proportions