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Task

BEACON CRI-Off: CRISPR off-target effect prediction

CRISPR off-target effect prediction. Reg at sequence level, scored with Spearman Corr. Dataset DeepCRISPR; train/validation/test 14,223/2,032/4,064.

17 evaluations · 17 results

Overview

CRISPR off-target effect prediction. Reg at sequence level, scored with Spearman Corr. Dataset DeepCRISPR; train/validation/test 14,223/2,032/4,064.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Results

Each comparison retains its reviewed evaluation scope, dataset and metric. Results are shown without a pooled ranking.

BEACON CRI-Off: CRISPR off-target effect prediction

spearman_corr (percent) · Higher values are better.

BEACON CRI-Off: CRISPR off-target effect prediction · DeepCRISPR (BEACON split)

Evidence origin: Author-reported evaluation.

BEACON: Benchmark for Comprehensive RNA Tasks and Language Models (arXiv:2406.10391v2) · Table3,p.8,column(CRI-Off)
  • The Literature SOTA row is excluded: those numbers come from other papers under their own protocols.
  • Metrics differ between tasks, so these figures cannot be averaged into one RNA score.
Comparison details and limitations

Every method in BEACON Table 3 on CRISPR off-target effect prediction, scored with Spearman Corr on DeepCRISPR with the split 14,223/2,032/4,064.

  • Author-reported numbers, source checked but not independently reproduced.

Automated source review: 2026-09-18. Numerical source review does not establish independent reproduction.

Dots show point estimates. Whiskers show only explicitly defined uncertainty (standard deviation, standard error or a labelled interval); their definitions remain in Table. Unresolved uncertainty is not plotted. Differences do not establish statistical significance.

Showing 12 of 17 matching rows.

Tested configuration
-12.185.368.5411.7
Reported score
  1. ResNet11.50(0.22)
  2. CNN11.40(0.10)
  3. LSTM8.60(0.13)
  4. Splice-MS10245.00(0.71)
  5. UTRBERT-6mer4.90(0.57)
  6. UTRBERT-3mer4.48(1.12)
  7. BEACON-B4.42(0.33)
  8. UTR-LM-MRL4.28(0.15)
  9. RNABERT4.27(1.05)
  10. Splice-H5104.00(1.13)
  11. UTRBERT-5mer3.93(0.24)
  12. RNA-MSM3.85(0.99)

Methods and evaluation design

Procedure, tasks and evaluated configurations

Evaluation design

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Benchmarks

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Recorded evaluations

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Run instructions

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Strengths, limitations and unresolved questions

Evidence

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Evidence table

Inspect claims, sources and review details

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statementOriginal source and locationReview and provenance
Relationship: part of
discovery-benchmark-beacon
Individual claims		BEACON: Benchmark for Comprehensive RNA Tasks and Language Models (arXiv:2406.10391v2)

Original source ↗

Table1,p.6,row(CRI-Off)

Version: v2, 12 December 2024
Retrieved: 2026-09-18

source checked

automated source review · 2026-09-18

Audit details

Primary-source transcription with no human sign-off and no independent reproduction.

Field: links:part_of:discovery-benchmark-beacon

Claim: beacon-association-cri-off

Source artifact SHA-256: 1370d75fe591bb8f994bc67f100a1a3fd557a62b9edb962b21f2fb038e9dea16

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

All evidence (CSV)All evidence (JSONL)How to read the evidence

Sources and history

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Release 2026-09-29-06401fd5b220 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: beacon-task-cri-off

areas
rna-transcriptomes
tasks
CRISPR off-target effect prediction
metric
Spearman Corr
metric direction
higher
task type
Reg
rna level
Sequence
dataset
DeepCRISPR
splits
14,223/2,032/4,064
source locator
Table1,p.6,row(CRI-Off)
comparison panels
id: beacon-panel-cri-off; title: BEACON CRI-Off: CRISPR off-target effect prediction; protocol id: beacon-task-cri-off; dataset id: beacon-dataset-deepcrispr; metric: spearman_corr; unit: percent; direction: higher; result ids: beacon-result-cnn-cri-off-spearman-corr; beacon-result-resnet-cri-off-spearman-corr; beacon-result-lstm-cri-off-spearman-corr; beacon-result-rna-fm-cri-off-spearman-corr; beacon-result-rnabert-cri-off-spearman-corr; beacon-result-rna-msm-cri-off-spearman-corr; beacon-result-splice-h510-cri-off-spearman-corr; beacon-result-splice-ms510-cri-off-spearman-corr; beacon-result-splice-ms1024-cri-off-spearman-corr; beacon-result-utr-lm-mrl-cri-off-spearman-corr; beacon-result-utr-lm-te-and-el-cri-off-spearman-corr; beacon-result-utrbert-3mer-cri-off-spearman-corr; beacon-result-utrbert-4mer-cri-off-spearman-corr; beacon-result-utrbert-5mer-cri-off-spearman-corr; beacon-result-utrbert-6mer-cri-off-spearman-corr; beacon-result-beacon-b-cri-off-spearman-corr; beacon-result-beacon-b512-cri-off-spearman-corr; source ids: source-beacon-arxiv-2406-10391; source locator: Table3,p.8,column(CRI-Off); context: Every method in BEACON Table 3 on CRISPR off-target effect prediction, scored with Spearman Corr on DeepCRISPR with the split 14,223/2,032/4,064.; caveats: Author-reported numbers, source checked but not independently reproduced.; The Literature SOTA row is excluded: those numbers come from other papers under their own protocols.; Metrics differ between tasks, so these figures cannot be averaged into one RNA score.; review: method: automated_source_review; date: 2026-09-18
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