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Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system

Primary source inspected for the scoped extraction; automated review does not establish replication.

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16 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-06-fea06f63ac0e
Property and statement	Original source and location	Review and provenance
attributes.artifact_retrieved_at 2026-10-05T14:02:27Z Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_retrieved_at` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.artifact_sha256 2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_sha256` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.artifact_url https://pmc.ncbi.nlm.nih.gov/articles/PMC11869971/ Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.artifact_url` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.doi 10.1016/j.gimo.2024.101961 Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.doi` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.publication_status peer_reviewed Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.publication_status` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.retrieved_at 2026-10-05T14:02:27Z Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.retrieved_at` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.url https://pmc.ncbi.nlm.nih.gov/articles/PMC11869971/ Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.url` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.version 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `attributes.version` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
description Primary source inspected for the scoped extraction; automated review does not establish replication. Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
facets.areas 1 values dna-genomes Source metadata	Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Original source ↗ No field-specific location recorded Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied Retrieved: 2026-10-05T14:02:27Z	catalogued No individual claim review recorded Audit details Field: `facets.areas` Source artifact SHA-256: `2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-06-fea06f63ac0e · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: uc-clinical-20261005-source-benet-pages

areas: dna-genomes
contexts: clinical_research
url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11869971/
retrieved at: 2026-10-05T14:02:27Z
version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied
publication status: peer_reviewed
doi: 10.1016/j.gimo.2024.101961
artifact sha256: 2e458cacad35cca0507753c43c5104b75217593a0c2fdbd16143f0391fba33eb
artifact url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11869971/
artifact retrieved at: 2026-10-05T14:02:27Z

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