20% reclassified_to_lb_fraction
Benet-Pages t2 (ACMG/AMP + SVI): reclassified_to_lb_fraction
- Tested configuration
- ACMG/AMP classification system with SVI recommendations (t2)
- Protocol
- Benet-Pages BRCA1/BRCA2 VUS reclassification: ACMG/AMP + SVI step (t2)
- Dataset
- Benet-Pages 2025 BRCA1/BRCA2 VUS reclassification cohort
- Procedure
- Not reported
- Evaluation
- Benet-Pages t2 (ACMG/AMP + SVI) reclassification of the 121-variant VUS cohort
- Coverage
- scored: unreported; eligible: unreported
- Uncertainty
- Not reported
- Evidence
- Author-reported evaluation · source checkedReclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system · Results, "Reclassification of variants using the ACMG/AMP classification system with SVI recommendations and new data (ACMG/AMP + SVI)": "Of 121 VUS, 20% (n = 24) were reclassified as LB..."
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Not reported
- Adaptation
- Not reported
- Scoring implementation
- Source-defined endpoint; see result source_locator
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 20% Individual claims | Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system Results, "Reclassification of variants using the ACMG/AMP classification system with SVI recommendations and new data (ACMG/AMP + SVI)": "Of 121 VUS, 20% (n = 24) were reclassified as LB..." Version: 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied | source checked automated source review · 2026-10-05 author reported Audit detailsTranscription from inspected primary source. No execution, independent replication or human scientific review. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
View linked audit checks and correction history
Release 2026-10-06-fea06f63ac0e · Record review: source checked
1 source records and release history
- Reclassification of VUS in BRCA1 and BRCA2 using the new BRCA1/BRCA2 ENIGMA track set demonstrates the superiority of ClinGen ENIGMA Expert Panel specifications over the standard ACMG/AMP classification system · Original source · 2025 published article (Genetics in Medicine Open); ENIGMA BRCA1/BRCA2 VCEP specification v1.1.0 applied
Technical metadata and extraction receipts
Stable ID: uc-clinical-20261005-benet-pages-t2-reclassified-lb-fraction
- areas
- dna-genomes
- contexts
- clinical_research
- metric
- reclassified_to_lb_fraction
- unit
- percent
- printed value
- 20%
- numeric value
- 20
- metric direction
- higher
- uncertainty
- Not reported
- denominator
- 121
- source locator
- Results, "Reclassification of variants using the ACMG/AMP classification system with SVI recommendations and new data (ACMG/AMP + SVI)": "Of 121 VUS, 20% (n = 24) were reclassified as LB..."
- review
- method: automated_source_review; reviewer: Claude Sonnet clinical coverage worker (research-evidence intake); date: 2026-10-05; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20261005-source-benet-pages
- missing metadata
- uncertainty: not reported for this endpoint