Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML
Nature, version of record 28 January 2026; PMC12851941 full-text XML · Peer-reviewed
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Claims
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- AlphaGenome distilled model time per variant: Inference hardware The distilled student model makes predictions for all modalities and cell types with a single device call per variant, taking less than 1 s on an NVIDIA H100 GPU. (Results, 'Unifying DNA sequence-to-function model', paragraph 2: 'Taking less than 1 s on an NVIDIA H100 GPU, the student model is highly efficient for large-scale variant effect prediction relative to the alternative approach of ensembling several independently trained models.')
Evidence
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Evidence table
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17 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Artifact SHA-256 50d10530afd474d85702813bc9c9e5431406515e44f3425d64603fdb647fee13 Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact url https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12851941/fullTextXML Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Doi 10.1038/s41586-025-10014-0 Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Licence CC-BY-4.0 Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Media type application/xml Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Publication status peer_reviewed Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Retrieved at 2026-10-14T12:48:26Z Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Url https://doi.org/10.1038/s41586-025-10014-0 Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Version Nature, version of record 28 January 2026; PMC12851941 full-text XML Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description Primary article retrieved and hashed for the genomic foundation model guide sources pass (issue #138). The stored retrieval of the same URL (evidence-official-56e5abfb5f12f1cd3b20, 2026-09-16) has different bytes, so this retrieval is pinned separately. Source metadata | Advancing regulatory variant effect prediction with AlphaGenome (Nature), Europe PMC full-text XML No field-specific location recorded Version: Nature, version of record 28 January 2026; PMC12851941 full-text XML | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
Primary article retrieved and hashed for the genomic foundation model guide sources pass (issue #138). The stored retrieval of the same URL (evidence-official-56e5abfb5f12f1cd3b20, 2026-09-16) has different bytes, so this retrieval is pinned separately.
Technical metadata and extraction receipts
Stable ID: gfm-guide-20261014-source-alphagenome-article
- areas
- dna-genomes
- contexts
- research
- artifact url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12851941/fullTextXML
- retrieved at
- 2026-10-14T12:48:26Z
- artifact sha256
- 50d10530afd474d85702813bc9c9e5431406515e44f3425d64603fdb647fee13
- url
- https://doi.org/10.1038/s41586-025-10014-0
- doi
- 10.1038/s41586-025-10014-0
- publication status
- peer_reviewed
- licence
- CC-BY-4.0
- version
- Nature, version of record 28 January 2026; PMC12851941 full-text XML
- media type
- application/xml