ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery
2025 · version of record · Peer-reviewed
What this source contributed
Records in this release that cite this source. A record can cite several sources.
Results
Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.
| Model or configuration | Metric | Value | Dataset | Evaluation |
|---|---|---|---|---|
| ESM2_AMPS | AUROC | 0.68 unitless | Bernett PPI dataset | ESM2_AMPS: protein-protein interaction prediction |
Claims
Statements this source supports, each with where in the source it was checked.
- ESM2_AMP_CSE: uses model ESM-2: Uses model ESM-2 (Methods: ESM2_AMP_CSE and Transformer fusion of ESM2 features)
- ESM2_AMPS: description: Description Predicts binary protein-protein interactions from ESM-2 representations of sequence segments fused by a transformer encoder; AMPS is the segment-feature variant of the framework. (Reviewed profile (2026-09-16): summary at Methods/Construction of dual models based on feature integration (paragraph 3); Results/Attention mechanism reveal protein–protein interaction mechanism (paragraph 1); architecture fact at Methods/Interpretability analysis utilizing attention mechanisms (paragraph 1); Methods/Construction of dual models based on feature integration (paragraph 3); description text also read at Abstract)
- ESM2_AMPS: uses model ESM-2: Uses model ESM-2 (Methods: ESM2_AMP framework and ESM2_AMPS feature fusion)
- ESM2_AMPS: uses model ESM-2: Uses model ESM-2 (Methods: ESM2_AMPS and Transformer fusion of ESM2 segment features)
- ESM2_DPM: uses model ESM-2: Uses model ESM-2 (Methods: ESM2_DPM baseline; ESM2 feature representations)
- Reported AUROC for ESM2_AMPS: Printed value 0.68 (Table 4, ESM2_AMPS row, AUROC column)
Models, benchmarks and other records
Pipelines (1)
Tasks (1)
Datasets (1)
Evaluations (1)
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
18 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Artifact retrieved at 2026-09-16T10:33:58.625Z Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact SHA-256 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact url https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12392411/fullTextXML Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Doi 10.1093/bib/bbaf434 Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Missing metadata: licence: reason unextracted Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Publication status peer_reviewed Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Retrieved at 2026-09-15T23:37:05Z Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scope decision included Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Url https://pmc.ncbi.nlm.nih.gov/articles/PMC12392411/ Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Version version of record Source metadata | ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery No field-specific location recorded Version: version of record | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: discovered
Primary paper retained with its original identifier. Metadata inherited from the literature collection; individual result checks are separate.
Technical metadata and extraction receipts
Stable ID: esm2-amp-2025
- areas
- molecular-interactions
- url
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12392411/
- version
- version of record
- retrieved at
- 2026-09-15T23:37:05Z
- doi
- 10.1093/bib/bbaf434
- publication status
- peer_reviewed
- year
- 2025
- artifact sha256
- 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c
- artifact url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12392411/fullTextXML
- artifact retrieved at
- 2026-09-16T10:33:58.625Z
- scope decision
- included
- missing metadata
- licence: reason: unextracted