Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization
2026 · preprint version in PMC · Preprint
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Results
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| Model or configuration | Metric | Value | Dataset | Evaluation |
|---|---|---|---|---|
| ARSENAL+ChromBPNet | AUROC | 0.896 unitless | Yoruban LCL dsQTLs | ARSENAL+ChromBPNet: regulatory-variant scoring |
Claims
Statements this source supports, each with where in the source it was checked.
- ARSENAL+ChromBPNet: description: Description Supervised chromatin-accessibility and regulatory-variant predictor in which embeddings from ARSENAL, a short-context masked DNA language model trained with motif-discovery regularisation, are added to ChromBPNet inputs. (Reviewed profile (2026-09-16): summary at Results/ARSENAL embeddings improve supervised sequence models of chromatin accessibility (paragraph 2); Results/ARSENAL embeddings improve supervised sequence models of chromatin accessibility (paragraph 1); architecture fact at Abstract (paragraph 1); Results/The ARSENAL model: targeted pretraining with motif discovery regularization (paragraph 2); description text also read at Abstract)
- ARSENAL+ChromBPNet: uses model ChromBPNet: Uses model ChromBPNet (ARSENAL primary paper ChromBPNet-based supervised models and Table 1 | Existing reviewed locator: Results/ARSENAL embeddings improve supervised sequence models of chromatin accessibility (paragraph 2); Results/ARSENAL embeddings improve supervised sequence models of chromatin accessibility (paragraph 1))
- Reported AUROC for ARSENAL+ChromBPNet: Printed value 0.896 (Table 1, Yoruban LCL dsQTLs section, ARSENAL+ChromBPNet row, AUROC column)
Models, benchmarks and other records
Pipelines (1)
Tasks (1)
Datasets (1)
Evaluations (1)
Evidence
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18 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Artifact retrieved at 2026-09-16T10:41:06Z Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact SHA-256 4a264956e47fc633aaff6573aac368dc691dd5de709b27c7421c078608ff542a Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact url https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12889687/fullTextXML Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Doi 10.64898/2026.02.05.703637 Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Missing metadata: licence: reason unextracted Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Publication status preprint Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Retrieved at 2026-09-15T23:37:05Z Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scope decision included Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Url https://pmc.ncbi.nlm.nih.gov/articles/PMC12889687/ Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Version preprint version in PMC Source metadata | Short-Context Regulatory DNA Language Models with Motif-Discovery Regularization No field-specific location recorded Version: preprint version in PMC | catalogued No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: discovered
Primary paper retained with its original identifier. Metadata inherited from the literature collection; individual result checks are separate.
Technical metadata and extraction receipts
Stable ID: arsenal-regulatory-dna-2026
- areas
- dna-genomes
- url
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12889687/
- version
- preprint version in PMC
- retrieved at
- 2026-09-15T23:37:05Z
- doi
- 10.64898/2026.02.05.703637
- publication status
- preprint
- year
- 2026
- artifact sha256
- 4a264956e47fc633aaff6573aac368dc691dd5de709b27c7421c078608ff542a
- artifact url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12889687/fullTextXML
- artifact retrieved at
- 2026-09-16T10:41:06Z
- scope decision
- included
- missing metadata
- licence: reason: unextracted