ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
Supervised clinical predictors from dbNSFP ranked by AUC for pathogenic versus benign clinical substitutions, averaged over proteins.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
17 recorded evaluations, 17 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.
Results
Results are available, but no reviewed comparison panel is linked in this release.
All evaluations
17 evaluations · 17 results. Different protocols are not a single leaderboard.
Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) · Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22
Sorted by AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
All 17 result rows with coverage, uncertainty and sources
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: BayesDel (addAF) [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.972 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.001 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 4, row 'BayesDel (addAF)', column 'Average_AUC' |
| Configuration: BayesDel (noAF) [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.925 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 7, row 'BayesDel (noAF)', column 'Average_AUC' |
| Configuration: CADD [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.905 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceCADD: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 11, row 'CADD', column 'Average_AUC' |
| Configuration: ClinPred [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.981 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.0 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceClinPred: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 2, row 'ClinPred', column 'Average_AUC' |
| Configuration: DANN [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.812 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.004 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceDANN: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 17, row 'DANN', column 'Average_AUC' |
| Configuration: DEOGEN2 [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.894 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.004 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceDEOGEN2: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 13, row 'DEOGEN2', column 'Average_AUC' |
| Configuration: FATHMM [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.723 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.006 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceFATHMM: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 18, row 'FATHMM', column 'Average_AUC' |
| Configuration: gMVP [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.914 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.004 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourcegMVP: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 10, row 'gMVP', column 'Average_AUC' |
| Configuration: MetaRNN [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.977 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.001 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceMetaRNN: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 3, row 'MetaRNN', column 'Average_AUC' |
| Configuration: MPC [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.881 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.004 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceMPC: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 14, row 'MPC', column 'Average_AUC' |
| Configuration: MutationTaster [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.816 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.004 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 16, row 'MutationTaster', column 'Average_AUC' |
| Configuration: PolyPhen2 (HDIV) [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.879 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.004 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 15, row 'PolyPhen2 (HDIV)', column 'Average_AUC' |
| Configuration: PolyPhen2 (HVAR) [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.896 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 12, row 'PolyPhen2 (HVAR)', column 'Average_AUC' |
| Configuration: REVEL [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.928 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceREVEL: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 6, row 'REVEL', column 'Average_AUC' |
| Configuration: VARITY (ER) [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.918 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceVARITY (ER): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 9, row 'VARITY (ER)', column 'Average_AUC' |
| Configuration: VARITY (R) [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.921 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceVARITY (R): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 8, row 'VARITY (R)', column 'Average_AUC' |
| Configuration: VEST4 [ProteinGym 144fe22 clinical summary] | Protocol: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Dataset subset: ProteinGym clinical substitution benchmark at commit 144fe22 | 0.929 AUROC (ProteinGym clinical substitutions, supervised clinical predictors, Average_AUC over proteins) unitless · higher Uncertainty: ± 0.003 (type not stated). Labelled a bootstrap standard error. The script that wrote the clinical summary was not read; in the DMS script the same column is the standard error of the difference from the top model, and the top row here prints 0.0, which suggests the same construction. Not verified for this file. Coverage: Not reported scored / Not reported eligible | Evaluation origin not reported · Source checkedMethods, coverage and sourceVEST4: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22) Aggregation: Not reported ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv line 5, row 'VEST4', column 'Average_AUC' |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
Each evaluation records what was tested and under which conditions.
- BayesDel (addAF): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- BayesDel (noAF): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- CADD: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- ClinPred: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- DANN: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- DEOGEN2: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- FATHMM: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- gMVP: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- MetaRNN: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- MPC: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- MutationTaster: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- PolyPhen2 (HDIV): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
Baseline coverage
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- 17
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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
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Strengths, limitations and unresolved questions
Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
3 source records and release history
- ProteinGym clinical supervised substitutions AUC summary at commit 144fe22 · Original source · 144fe22b07dfaeec2b366f2346203a9838a55b4c
- OATML-Markslab/ProteinGym / README.md · Original source · Git commit 144fe22b07dfaeec2b366f2346203a9838a55b4c
- Protocol metadata evidence: proteingym-paper.xml · Original source · PMC10723403 retrieved 2026-09-23
Technical metadata and extraction receipts
Stable ID: vep-lit-20261014-protocol-proteingym-clinical-supervised-substitutions-auc-144fe22
- areas
- proteins-complexes; dna-genomes
- contexts
- clinical_research
- task
- Clinical substitution pathogenicity classification, supervised predictors
- metric
- auroc
- metric direction
- higher
- unit
- unitless
- metric qualifier
- Average_AUC column of the ProteinGym clinical summary file
- version
- 144fe22b07dfaeec2b366f2346203a9838a55b4c
- upstream revision
- 144fe22b07dfaeec2b366f2346203a9838a55b4c
- publication status
- official_project_source
- source locator
- benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv; README.md lines 39-52 and 106
- limitations
- The README says per-protein AUC is the clinical metric and gives dbNSFP 4.4a as the source of clinical baselines; the script that wrote this summary file was not read, so the averaging and the bootstrap standard error are not verified for this file.; Supervised clinical predictors were trained on clinical labels that may overlap the benchmark's variants; ProteinGym's summary does not remove them.; The ProteinGym paper describes the clinical substitution set as ClinVar labels processed as in EVE (Frazer et al. 2021) and the indel set as short in-frame ClinVar indels (up to 3 amino acids, frameshifts filtered out) with common gnomAD indels as benign pseudocontrols, because 84% of ClinVar indel annotations are pathogenic. The paper describes the 2023 release; whether the sets behind the 144fe22 files are unchanged is not stated.; Not comparable with the DMS summaries or with Livesey and Marsh's rank scores.
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T15:30:00Z; artifact sha256: f2e38aeac2624d87e7a35a5b16bd580de62c24db36973848e1d94ac3ce510359; retrieval url: https://raw.githubusercontent.com/OATML-Markslab/ProteinGym/144fe22b07dfaeec2b366f2346203a9838a55b4c/benchmarks/clinical_supervised/substitutions/AUC/Summary_performance_clinical_substitutions_AUC.csv; method: ai-assisted-source-review; scope-review; method note: Descriptive fields, identity links and missing-metadata reasons checked against the cited sources.; note: Checked; see the dated review for rulings on identity and method type.
Related records
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- uses data: ProteinGym clinical substitution benchmark at commit 144fe22
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- assessment: BayesDel (addAF): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: BayesDel (noAF): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: CADD: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: ClinPred: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: DANN: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: DEOGEN2: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: FATHMM: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: gMVP: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: MetaRNN: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: MPC: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: MutationTaster: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: PolyPhen2 (HDIV): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: PolyPhen2 (HVAR): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: REVEL: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: VARITY (ER): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: VARITY (R): ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)
- assessment: VEST4: ProteinGym clinical substitutions, supervised predictors, average AUC (commit 144fe22)