rewirebio.iobenchmarks
Protocol

Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions

Cell embeddings (or the 2,000-HVG expression matrix) of each dataset scored for cell-type separation (ASW, NMI, ARI, AvgBIO) and batch mixing (batch integration ASW, PCR, average batch score) in the full embedding dimensions.

56 evaluations · 416 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

56 recorded evaluations, 416 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

56 evaluations · 416 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
8 Rank (overall average ranking across datasets, based on mean biological-conservation and batch-mixing scores (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS4' cell B10, row 'Geneformer', column 'Average ranking'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
7 Rank (rank of the median ARI score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell D9, row 'Geneformer', column 'ARI'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
8 Rank (rank of the median ASW score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell C9, row 'Geneformer', column 'ASW'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
8 Rank (rank of the median Average batch score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell F9, row 'Geneformer', column 'Average batch'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
7 Rank (rank of the median Average BIO score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell B9, row 'Geneformer', column 'Average BIO'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
7 Rank (rank of the median Batch integration score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell G9, row 'Geneformer', column 'Batch integration'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
8 Rank (rank of the median NMI score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell E9, row 'Geneformer', column 'NMI'
Configuration: Geneformer (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
8 Rank (rank of the median PCR score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell H9, row 'Geneformer', column 'PCR'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
2 Rank (overall average ranking across datasets, based on mean biological-conservation and batch-mixing scores (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS4' cell B4, row 'Harmony', column 'Average ranking'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
2 Rank (rank of the median ARI score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell D4, row 'Harmony', column 'ARI'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
1 Rank (rank of the median ASW score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell C4, row 'Harmony', column 'ASW'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
2 Rank (rank of the median Average batch score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell F4, row 'Harmony', column 'Average batch'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
2 Rank (rank of the median Average BIO score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell B4, row 'Harmony', column 'Average BIO'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
8 Rank (rank of the median Batch integration score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell G4, row 'Harmony', column 'Batch integration'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
2 Rank (rank of the median NMI score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell E4, row 'Harmony', column 'NMI'
Configuration: Harmony (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
2 Rank (rank of the median PCR score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Harmony cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell H4, row 'Harmony', column 'PCR'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
3 Rank (overall average ranking across datasets, based on mean biological-conservation and batch-mixing scores (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS4' cell B5, row 'HVG', column 'Average ranking'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
3 Rank (rank of the median ARI score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell D5, row 'HVG', column 'ARI'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
5 Rank (rank of the median ASW score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell C5, row 'HVG', column 'ASW'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
4 Rank (rank of the median Average batch score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell F5, row 'HVG', column 'Average batch'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
3 Rank (rank of the median Average BIO score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell B5, row 'HVG', column 'Average BIO'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
1 Rank (rank of the median Batch integration score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell G5, row 'HVG', column 'Batch integration'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
3 Rank (rank of the median NMI score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell E5, row 'HVG', column 'NMI'
Configuration: 2,000 highly variable genes (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
4 Rank (rank of the median PCR score across datasets among the eight representations (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HVG cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS3' cell H5, row 'HVG', column 'PCR'
Configuration: scGPT blood (Kedzierska et al. 2025)Protocol: Kedzierska et al. 2025 cell embedding scoring, full embedding dimensions
Dataset subset: Evaluated datasets, aggregated (Kedzierska et al. 2025)
4 Rank (overall average ranking across datasets, based on mean biological-conservation and batch-mixing scores (1 = best); full embedding dimensions)
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scGPT blood cell embedding on evaluated datasets (Kedzierska et al. 2025)

gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

Aggregation: Not reported

Kedzierska et al. 2025, Additional file 1 (Supplementary Tables S1-S7, xlsx) · Additional file 1, sheet 'TableS4' cell B6, row 'scGPT blood', column 'Average ranking'

Source checking is not independent reproduction. Release 2026-10-23-5347695500ed.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Recorded evaluations

Each evaluation records what was tested and under which conditions.

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Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

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External evaluations
56

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Null control

Proposed control: requires review

Unintegrated representation using protocol preprocessing

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)

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Technical metadata and extraction receipts

Stable ID: gfm-guides-20261014-kedzierska2025-protocol-cell-embedding

areas
single-cell
contexts
research
protocol
Embed each whole dataset; compute scIB metrics against the dataset's cell-type and batch labels in the full embedding dimensions.
version
Genome Biology 26:101
metric implementation
scib 1.0.4. ASW of cell-type labels rescaled to [0, 1]; NMI and ARI on Louvain clusters at the resolution with the highest NMI out of 20; batch integration = 1 minus absolute batch silhouette per cell type, averaged; PCR = change in variance explained by batch between the original data and the embedding (Methods, pages 9-10).
unit
unitless
limitations
One run on each whole dataset; spread across 10 repeats of 10% subsamples is printed separately and not extracted.; scVI and Harmony are trained on each target dataset; scGPT and Geneformer are not trained on it.
source locator
Pages 9-10 'Biological preservation scores', 'Batch mixing scores'; Additional file 1 sheet TableS6
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