AlphaProteo
AlphaProteo generates binder structures and sequences conditioned on a target structure and selects which candidates to test with a learned filter.
Results are recorded on linked configurations and versions of this pipeline. Their settings and evaluations are kept separate below.
Results on linked records
This pipeline has no results of its own in this release. 4 linked records have results. They are not assigned to the underlying pipeline: each record keeps its own settings and evaluations, and its scores are on its own page.
- AlphaProteo, pooled over tested design systems Configuration · configuration · 43 evaluations · 43 results
- AlphaProteo v1 Configuration · configuration · 17 evaluations · 17 results
- AlphaProteo v1 with improved filters Configuration · configuration · 4 evaluations · 4 results
- AlphaProteo v2 Configuration · configuration · 5 evaluations · 5 results
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this pipeline
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Original source · arXiv version 1, posted 2024-09-12; full-text PDF (49 pages)
Technical metadata and extraction receipts
Stable ID: uc-binder-20261022-pipeline-alphaproteo
- areas
- proteins-complexes; protein-structure
- contexts
- research
- method types
- specialist
- access
- Not released. The paper describes a closed system.
- provenance note
- Created from the AlphaProteo preprint for the 2026-10-22 binder design pass.
- reported name
- AlphaProteo
- review
- artifact sha256: 953b35644c0fa06ff090d7614c2e19525831f8fde50242e176d54474133c5a42; method: source-hash-verification; independent-cell-check; ai-assisted-source-review; method note: Re-downloaded with curl (HTTP 200, 12,333,400 bytes) and the SHA-256 recomputed and matched. Own text layer made with pdftotext -layout (poppler 26.08.0), reproducing the extraction pass's 2,811 lines. Table 1, Table S2, Table S3 and Sections S1.2.1, S2, S4.1 and S4.2 read cell by cell and compared with every record. Column assignment re-derived arithmetically rather than trusted.; note: Reviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally.; retrieval url: https://arxiv.org/pdf/2409.08022v1; reviewed at: 2026-10-22T15:00:00Z; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed
- source locator
- Section 2, Figure 1A
- version
- v1 and v2 generative models, as reported in arXiv:2409.08022v1
Related records
- subject: AlphaProteo Table 1 'Other design methods' rows are copied from other publications
- configuration of: AlphaProteo, pooled over tested design systems
- configuration of: AlphaProteo v1
- configuration of: AlphaProteo v1 with improved filters
- configuration of: AlphaProteo v2