AlphaProteo Table 1 'Other design methods' rows are copied from other publications
Compilation rows not extracted of AlphaProteo
Table 1, row 'Other design methods', Experimental success rate (%): BHRF1 18 a (17); SC2RBD 1.6 b (63); IL-7RA 0.15 c (14,912); PD-L1 13 b (16); TrkA 0.07 c (14,982); IL-17A 0.02 d (15,000); VEGF-A and TNF-alpha print an en dash. Table 1, row 'Other design methods', Binding KD (nM): BHRF1 58 a (17); SC2RBD 100 e (100,000); IL-7RA 3 c (14,912); PD-L1 0.9 b (16); TrkA 3000 c (14,982); IL-17A 47 d (15,000). Table 1, row 'Other design methods, optimized', Binding KD (nM): BHRF1 16*,a; SC2RBD 16*,e; IL-7RA 0.31 c; PD-L1 0.65 f; TrkA 1.4 c; IL-17A 0.01 d. Footnotes: a Procko et al. [35]; b Gainza et al. [11]; c Cao et al. [6]; d Berger et al. [3]; e Cao et al. [5]; f Yang et al. [45]. Table S2, row 'RFdiffusion (published)', Success (%): IL-7RA 33.7 (95); PD-L1 12.6 (95); TrkA 6.3 (95). Table S2, row 'RFdiffusion (published)', Binding KD (nM): IL-7RA 30 (95); PD-L1 1400 (95); TrkA 328 (95). Not recorded as results because the values are copied from publications this pass did not retrieve, and because Section S4.2 states that the asterisked values were measured by the AlphaProteo authors themselves by HTRF and that for PD-L1 they substituted a different design (RFD_PDL1_76, KD 1.6 nM) for the published best design (RFD_PDL1_77, KD 1.4 micromolar). That is a third party's reanalysis of another group's result.
The 'Other design methods' and 'Other design methods, optimized' rows of Table 1, and the 'RFdiffusion (published)' row of Table S2, copy values from other publications, and some of those values were re-measured by the AlphaProteo authors. They are recorded here as a transcription rather than as results.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field compilation_rows_not_extracted Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Source location Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Claimed value Table 1, row 'Other design methods', Experimental success rate (%): BHRF1 18 a (17); SC2RBD 1.6 b (63); IL-7RA 0.15 c (14,912); PD-L1 13 b (16); TrkA 0.07 c (14,982); IL-17A 0.02 d (15,000); VEGF-A and TNF-alpha print an en dash. Table 1, row 'Other design methods', Binding KD (nM): BHRF1 58 a (17); SC2RBD 100 e (100,000); IL-7RA 3 c (14,912); PD-L1 0.9 b (16); TrkA 3000 c (14,982); IL-17A 47 d (15,000). Table 1, row 'Other design methods, optimized', Binding KD (nM): BHRF1 16*,a; SC2RBD 16*,e; IL-7RA 0.31 c; PD-L1 0.65 f; TrkA 1.4 c; IL-17A 0.01 d. Footnotes: a Procko et al. [35]; b Gainza et al. [11]; c Cao et al. [6]; d Berger et al. [3]; e Cao et al. [5]; f Yang et al. [45]. Table S2, row 'RFdiffusion (published)', Success (%): IL-7RA 33.7 (95); PD-L1 12.6 (95); TrkA 6.3 (95). Table S2, row 'RFdiffusion (published)', Binding KD (nM): IL-7RA 30 (95); PD-L1 1400 (95); TrkA 328 (95). Not recorded as results because the values are copied from publications this pass did not retrieve, and because Section S4.2 states that the asterisked values were measured by the AlphaProteo authors themselves by HTRF and that for PD-L1 they substituted a different design (RFD_PDL1_76, KD 1.6 nM) for the published best design (RFD_PDL1_77, KD 1.4 micromolar). That is a third party's reanalysis of another group's result. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Description The 'Other design methods' and 'Other design methods, optimized' rows of Table 1, and the 'RFdiffusion (published)' row of Table S2, copy values from other publications, and some of those values were re-measured by the AlphaProteo authors. They are recorded here as a transcription rather than as results. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Relationship: subject uc-binder-20261022-pipeline-alphaproteo Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Name AlphaProteo Table 1 'Other design methods' rows are copied from other publications Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Original source · arXiv version 1, posted 2024-09-12; full-text PDF (49 pages)
Technical metadata and extraction receipts
Stable ID: uc-binder-20261022-claim-alphaproteo-other-design-methods-compilation
- field
- compilation_rows_not_extracted
- review
- artifact sha256: 953b35644c0fa06ff090d7614c2e19525831f8fde50242e176d54474133c5a42; method: source-hash-verification; independent-cell-check; ai-assisted-source-review; method note: Re-downloaded with curl (HTTP 200, 12,333,400 bytes) and the SHA-256 recomputed and matched. Own text layer made with pdftotext -layout (poppler 26.08.0), reproducing the extraction pass's 2,811 lines. Table 1, Table S2, Table S3 and Sections S1.2.1, S2, S4.1 and S4.2 read cell by cell and compared with every record. Column assignment re-derived arithmetically rather than trusted.; note: Reviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally.; retrieval url: https://arxiv.org/pdf/2409.08022v1; reviewed at: 2026-10-22T15:00:00Z; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed
- source locator
- Table 1, rows 'Other design methods' and 'Other design methods, optimized'; Table S2, row 'RFdiffusion (published)'; Sections S4.1 and S4.2
- value
- Table 1, row 'Other design methods', Experimental success rate (%): BHRF1 18 a (17); SC2RBD 1.6 b (63); IL-7RA 0.15 c (14,912); PD-L1 13 b (16); TrkA 0.07 c (14,982); IL-17A 0.02 d (15,000); VEGF-A and TNF-alpha print an en dash. Table 1, row 'Other design methods', Binding KD (nM): BHRF1 58 a (17); SC2RBD 100 e (100,000); IL-7RA 3 c (14,912); PD-L1 0.9 b (16); TrkA 3000 c (14,982); IL-17A 47 d (15,000). Table 1, row 'Other design methods, optimized', Binding KD (nM): BHRF1 16*,a; SC2RBD 16*,e; IL-7RA 0.31 c; PD-L1 0.65 f; TrkA 1.4 c; IL-17A 0.01 d. Footnotes: a Procko et al. [35]; b Gainza et al. [11]; c Cao et al. [6]; d Berger et al. [3]; e Cao et al. [5]; f Yang et al. [45]. Table S2, row 'RFdiffusion (published)', Success (%): IL-7RA 33.7 (95); PD-L1 12.6 (95); TrkA 6.3 (95). Table S2, row 'RFdiffusion (published)', Binding KD (nM): IL-7RA 30 (95); PD-L1 1400 (95); TrkA 328 (95). Not recorded as results because the values are copied from publications this pass did not retrieve, and because Section S4.2 states that the asterisked values were measured by the AlphaProteo authors themselves by HTRF and that for PD-L1 they substituted a different design (RFD_PDL1_76, KD 1.6 nM) for the published best design (RFD_PDL1_77, KD 1.4 micromolar). That is a third party's reanalysis of another group's result.
Related records
- subject: AlphaProteo