GPN-Star
Genomic pretrained network with species tree and alignment representations: a genomic language model with a phylogeny-aware architecture that uses whole-genome alignments and species trees, trained at vertebrate, mammal and primate timescales, for variant effect prediction in coding and non-coding regions of the human genome; also trained for five model organisms.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
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Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Ye et al. 2026, Nature (publisher PDF) · Original source · Nature accelerated article preview PDF ('Published online: xx xx xxxx'; accepted 2026-08-07)
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-model-gpn-star
- areas
- dna-genomes
- contexts
- research; clinical_research
- method types
- foundation_model
- reported name
- GPN-Star
- entity level
- family
- access
- Code at https://github.com/songlab-cal/gpn; models on Hugging Face (Data and code availability)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- licence
- Not stated for the model in the captured source
- training data
- Whole-genome alignments with species trees at vertebrate, mammal and primate timescales (Abstract)
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: 97f61ec05d4ace41692549290db3faf019ce869459459d2c5694bf54e16d0996; retrieval url: https://www.nature.com/articles/s41586-026-11005-5.pdf; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.