| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.3 overall_accuracy fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Fig1c Overall Accuracy; Section 3 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.75 diagnostic_micro_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Figure 1c, diagnostic row, alone column |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0 diagnostic_negative_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Diagnostic / Negative, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0 diagnostic_negative_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Diagnostic / Negative, precision |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0 diagnostic_negative_recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Diagnostic / Negative, recall |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.86 diagnostic_positive_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Diagnostic / Positive, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 1 diagnostic_positive_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Diagnostic / Positive, precision |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.75 diagnostic_positive_recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Diagnostic / Positive, recall |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.67 functional_dominant_negative_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Dominant Negative, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 1 functional_dominant_negative_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Dominant Negative, precision |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.5 functional_dominant_negative_recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Dominant Negative, recall |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.57 functional_micro_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Figure 1c, functional row, alone column |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.67 functional_gain_of_function_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Gain of Function, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.75 functional_gain_of_function_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Gain of Function, precision |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.6 functional_gain_of_function_recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Gain of Function, recall |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.55 functional_loss_of_function_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Loss of Function, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.6 functional_loss_of_function_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Loss of Function, precision |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.5 functional_loss_of_function_recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Loss of Function, recall |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0 functional_unaltered_function_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Unaltered Function, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0 functional_unaltered_function_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Unaltered Function, precision |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0 functional_unaltered_function_recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Functional / Unaltered Function, recall |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.46 micro_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Fig1c Micro F1; Section 3 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.2 oncogenic_micro_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Figure 1c, oncogenic row, alone column |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.2 oncogenic_oncogenicity_f1 F1 score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Oncogenic / Oncogenicity, f1 |
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| Configuration: GPT-5 2025-08-07 alone, CIViC March 2026 | Protocol: CIViC evidence-direction retrieval, March 2026 Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026 | 0.25 oncogenic_oncogenicity_precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceCIViC alone retrieval Not reported Aggregation: Not reported CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 2, Oncogenic / Oncogenicity, precision |
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