rewire.itbenchmarks
Dataset

CIViC 100 molecular-profile/disease/therapy triplets, March 2026

100 random triplets, each queried for 23 evidence-type/significance labels. Labels are live CIViC records. No EGFR-specific performance slice is reported.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-09-30-e37e3ab1284d · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

3 evaluations · 162 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.83 overall_accuracy
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Fig1c Overall Accuracy; Section 3
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.84 diagnostic_micro_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Figure 1c, diagnostic row, agent column
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0 diagnostic_negative_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Diagnostic / Negative, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0 diagnostic_negative_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Diagnostic / Negative, precision
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0 diagnostic_negative_recall
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Diagnostic / Negative, recall
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.94 diagnostic_positive_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Diagnostic / Positive, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.89 diagnostic_positive_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Diagnostic / Positive, precision
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 diagnostic_positive_recall
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Diagnostic / Positive, recall
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_dominant_negative_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Dominant Negative, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_dominant_negative_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Dominant Negative, precision
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_dominant_negative_recall
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Dominant Negative, recall
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.88 functional_micro_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Figure 1c, functional row, agent column
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.67 functional_gain_of_function_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Gain of Function, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.75 functional_gain_of_function_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Gain of Function, precision
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.6 functional_gain_of_function_recall
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Gain of Function, recall
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.92 functional_loss_of_function_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Loss of Function, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.86 functional_loss_of_function_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Loss of Function, precision
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_loss_of_function_recall
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Loss of Function, recall
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_unaltered_function_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Unaltered Function, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_unaltered_function_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Unaltered Function, precision
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
1 functional_unaltered_function_recall
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Functional / Unaltered Function, recall
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.91 micro_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Fig1c Micro F1; Section 3
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.96 oncogenic_micro_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer · Figure 1c, oncogenic row, agent column
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.96 oncogenic_oncogenicity_f1
F1 score · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Oncogenic / Oncogenicity, f1
Configuration: ChatGPT Agent Mode, 2–7 March 2026 CIViC evaluationProtocol: CIViC evidence-direction retrieval, March 2026
Dataset: CIViC 100 molecular-profile/disease/therapy triplets, March 2026
0.92 oncogenic_oncogenicity_precision
fraction · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

CIViC agent retrieval

Not reported

Aggregation: Not reported

CIViC MCP supplementary methods and complete Tables 1–3 · Supplementary Table 3, Oncogenic / Oncogenicity, precision

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-30-e37e3ab1284d
Property and statementOriginal source and locationReview and provenance
attributes.archive_doi
10.5281/zenodo.20938836
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.archive_doi

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.labels_per_triplet
23
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.labels_per_triplet

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.path
eval_QA_experiment/data/QA_triplet_dataset.csv
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.path

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.repository
https://github.com/griffithlab/civic-mcp-server
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.repository

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.triplets
100
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.triplets

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

description
100 random triplets, each queried for 23 evidence-type/significance labels. Labels are live CIViC records. No EGFR-specific performance slice is reported.
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

name
CIViC 100 molecular-profile/disease/therapy triplets, March 2026
Context-only references
CIViC MCP supplementary methods and complete Tables 1–3

Original source ↗

No field-specific location recorded

Version: vbag209_supplementary_data.docx, final article supplement
Retrieved: 2026-09-30T21:25:48Z

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: 857b272f9f29b9cb35d4fba7f424ef31d664d8acf8a23475c7c626a452b2e9e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-30-e37e3ab1284d · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: uc-clinical-20260930-civic-100-data

areas
dna-genomes
contexts
clinical_research
triplets
100
labels per triplet
23
archive doi
10.5281/zenodo.20938836
repository
https://github.com/griffithlab/civic-mcp-server
path
eval_QA_experiment/data/QA_triplet_dataset.csv
Related records

Suggest a correction