Published designs re-tested by the AlphaProteo authors in their own assay; transcribed from the pinned source and not reproduced.
1 evaluation · 1 result. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Published RFdiffusion designs, re-synthesised and tested by the AlphaProteo authors | Protocol: AlphaProteo best per-target binder affinity by HTRF Dataset: AlphaProteo binder design target PD-L1 | 1.6* Dissociation constant (best KD among the 95 published RFdiffusion designs, measured by the AlphaProteo authors using HTRF (asterisk in Table 1)) nanomolar · lower Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceuc-binder-20261022-protocol-alphaproteo-htrf-kd Aggregation: Not reported De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table 1, 'Binding KD (nM)' block, row 'RFdiffusion', column 'PD-L1' |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified
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AlphaProteo best per-target binder affinity by HTRF
Metadata review: source checked. Unreported conditions prevent automatic comparisons.
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
22 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Candidate selection None by the AlphaProteo authors: the 95 designs are the ones published by the RFdiffusion authors. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: adaptation Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: aggregation Over the 95 published designs tested Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: budget Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: dataset version PD-L1, Table S1 input structure Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: inputs Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: metric implementation Best (lowest) KD, by HTRF Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: population Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: protocol id uc-binder-20261022-protocol-alphaproteo-htrf-kd Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: split Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'PD-L1', row 'RFdiffusion'; Section S4.1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-eval-alphaproteo-table1-rfdiffusion-kd-pdl1