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1 evaluation · 1 result. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: AlphaProteo, pooled over tested design systems | Protocol: AlphaProteo yeast-display binding screen, hit at binding signal above 0.2 Dataset: AlphaProteo binder design target TrkA | 9% Hit rate (yeast-display binding signal above 0.2, over designs tested; pooled over the AlphaProteo design systems tested for this target) percent · higher Uncertainty: Not reported by the source: No interval or replicate count is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAlphaProteo on TrkA, pooled over tested design systems (yeast-display hit rate, Table 1) uc-binder-20261022-protocol-alphaproteo-yeast-display-signal-0-2 Aggregation: Not reported De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table 1, 'Experimental success rate (%)' block, row 'AlphaProteo', column 'TrkA' |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified
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AlphaProteo yeast-display binding screen, hit at binding signal above 0.2
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21 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Candidate selection Authors' own automated filter chose the candidates to test. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: adaptation Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: aggregation Pooled over all designs tested for the target Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: budget 131 designs synthesised and assayed Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: dataset version TrkA, Table S1 input structure Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: inputs Target structure and hotspot residues Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: metric implementation Fraction of tested designs with a yeast-display binding signal above the stated threshold Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: population 131 designs tested against TrkA Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: protocol id uc-binder-20261022-protocol-alphaproteo-yeast-display-signal-0-2 Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Comparison: split Not reported Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TrkA', row 'AlphaProteo' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-eval-alphaproteo-table1-rate-trka