rewirebio.iobenchmarks
Evaluation

Random on Schmidt1 (Roohani et al. 2025)

Published comparison; transcribed, not reproduced.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 2 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Random selection (Roohani et al. 2025)Protocol: BioDiscoveryAgent 1-gene perturbation design: hit ratio after 5 rounds of 128 genes
Dataset: Schmidt et al. 2022 screen, interferon-gamma production in primary human T cells
0.037 recall
fraction · higher

Uncertainty: Not yet extracted: Appendix Table 7 prints one standard deviation over 10 runs for these values; not extracted in this pass.

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Random on Schmidt1 (Roohani et al. 2025)

tgtval-20261009-protocol-roohani2025-hitratio-round5

Aggregation: Not reported

BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments · Table 1, row 'Random', column 'All' under 'Schmidt1'
Configuration: Random selection (Roohani et al. 2025)Protocol: BioDiscoveryAgent 1-gene perturbation design: hit ratio after 5 rounds of 128 genes
Dataset: Schmidt et al. 2022 screen, interferon-gamma production in primary human T cells
0.035 recall
fraction · higher

Uncertainty: Not yet extracted: Appendix Table 7 prints one standard deviation over 10 runs for these values; not extracted in this pass.

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Random on Schmidt1 (Roohani et al. 2025)

tgtval-20261009-protocol-roohani2025-hitratio-round5

Aggregation: Not reported

BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments · Table 1, row 'Random', column 'N/E' under 'Schmidt1'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

tgtval-20261009-protocol-roohani2025-hitratio-round5

Configuration
Random selection (Roohani et al. 2025)
Protocol
BioDiscoveryAgent 1-gene perturbation design: hit ratio after 5 rounds of 128 genes
Dataset
Schmidt et al. 2022 screen, interferon-gamma production in primary human T cells
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-09
protocol id
tgtval-20261009-protocol-roohani2025-hitratio-round5
dataset version
Offline replay of the screen
split
No training split; 5 sequential selection rounds
population
Genes assayed by the Schmidt1 screen
inputs
Phenotype description and the responses revealed in previous rounds
adaptation
Selection only; no model fitting for the agent rows
metric implementation
Not reported
aggregation
Mean over 10 runs
budget
5 rounds x 128 genes

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
No training split; 5 sequential selection rounds
Adaptation
Selection only; no model fitting for the agent rows
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Selection only; no model fitting for the agent rows
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.aggregation
Mean over 10 runs
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.budget
5 rounds x 128 genes
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.dataset_version
Offline replay of the screen
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.inputs
Phenotype description and the responses revealed in previous rounds
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.metric_implementation
Not reported
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.population
Genes assayed by the Schmidt1 screen
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.protocol_id
tgtval-20261009-protocol-roohani2025-hitratio-round5
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.comparison.split
No training split; 5 sequential selection rounds
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

attributes.limitations
1 values
  • Run by the authors of the agent.
Context-only references
BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments

Original source ↗

Table 1, row 'Random', columns for 'Schmidt1'

Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025
Retrieved: 2026-10-09T20:51:27Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.limitations

Source artifact SHA-256: dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7

Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

1 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: tgtval-20261009-eval-roohani2025-random-schmidt2022-ifng

areas
cells-tissues
contexts
research
origin
author_reported
protocol
tgtval-20261009-protocol-roohani2025-hitratio-round5
version
Primary source as retrieved 2026-10-09
comparison
protocol id: tgtval-20261009-protocol-roohani2025-hitratio-round5; dataset version: Offline replay of the screen; split: No training split; 5 sequential selection rounds; population: Genes assayed by the Schmidt1 screen; inputs: Phenotype description and the responses revealed in previous rounds; adaptation: Selection only; no model fitting for the agent rows; metric implementation: Not reported; aggregation: Mean over 10 runs; budget: 5 rounds x 128 genes
source locator
Table 1, row 'Random', columns for 'Schmidt1'
limitations
Run by the authors of the agent.
missing metadata
comparison.metric implementation: reason: unreported
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