rewirebio.iobenchmarks
Evaluation

SPANR on POU1F1 exon 2 saturation MPSA

Published comparison; transcribed, not reproduced.

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Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

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Verified: Not verified

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Verified: Not verified

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Evaluation results

1 evaluation · 4 results. Different protocols are not a single leaderboard.

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Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: SPANR (Smith and Kitzman 2023)Protocol: POU1F1 exon 2 saturation MPSA: transcriptome-normalised sensitivity at a 10% background call rate (Smith and Kitzman Table S2)
Dataset: POU1F1 exon 2 saturation MPSA (Smith and Kitzman benchmark set)
0.583 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SPANR on POU1F1 exon 2 saturation MPSA

splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10

Aggregation: Not reported

Benchmarking splice variant prediction algorithms using massively parallel splicing assays; Smith and Kitzman 2023, Additional file 3 (Table S2) · Additional file 3 sheet 'Sensitivity 10% SDV', cell E6; row SPANR, column POU1F1
Configuration: SPANR (Smith and Kitzman 2023)Protocol: POU1F1 exon 2 saturation MPSA: transcriptome-normalised sensitivity at a 10% background call rate (Smith and Kitzman Table S2)
Dataset: POU1F1 exon 2 saturation MPSA (Smith and Kitzman benchmark set)
0.514 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SPANR on POU1F1 exon 2 saturation MPSA

splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10

Aggregation: Not reported

Benchmarking splice variant prediction algorithms using massively parallel splicing assays; Smith and Kitzman 2023, Additional file 3 (Table S2) · Additional file 3 sheet 'Sensitivity 10% SDV', cell E14; row Exon_SPANR, column POU1F1
Configuration: SPANR (Smith and Kitzman 2023)Protocol: POU1F1 exon 2 saturation MPSA: transcriptome-normalised sensitivity at a 10% background call rate (Smith and Kitzman Table S2)
Dataset: POU1F1 exon 2 saturation MPSA (Smith and Kitzman benchmark set)
0.769 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SPANR on POU1F1 exon 2 saturation MPSA

splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10

Aggregation: Not reported

Benchmarking splice variant prediction algorithms using massively parallel splicing assays; Smith and Kitzman 2023, Additional file 3 (Table S2) · Additional file 3 sheet 'Sensitivity 10% SDV', cell E22; row Intron_SPANR, column POU1F1
Configuration: SPANR (Smith and Kitzman 2023)Protocol: POU1F1 exon 2 saturation MPSA: transcriptome-normalised sensitivity at a 10% background call rate (Smith and Kitzman Table S2)
Dataset: POU1F1 exon 2 saturation MPSA (Smith and Kitzman benchmark set)
0.7 recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

SPANR on POU1F1 exon 2 saturation MPSA

splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10

Aggregation: Not reported

Benchmarking splice variant prediction algorithms using massively parallel splicing assays; Smith and Kitzman 2023, Additional file 3 (Table S2) · Additional file 3 sheet 'Sensitivity 10% SDV', cell E30; row Intron_NonCanon_SPANR, column POU1F1

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10

Configuration
SPANR (Smith and Kitzman 2023)
Protocol
POU1F1 exon 2 saturation MPSA: transcriptome-normalised sensitivity at a 10% background call rate (Smith and Kitzman Table S2)
Dataset
POU1F1 exon 2 saturation MPSA (Smith and Kitzman benchmark set)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
dataset version
Smith and Kitzman benchmark set (Additional file 2)
split
No split
population
Saturation minigene MPSA of POU1F1 exon 2 (alpha and beta acceptors).
inputs
SNV in genomic context with one MANE Select canonical transcript (SQUIRLS: default hg19 Ensembl)
adaptation
None; published models or precomputed scores
metric implementation
Sensitivity at the tool threshold calling 10% of the 500,000-SNV background set
aggregation
Pooled over the dataset's variants, by variant class
budget
Not reported
protocol id
splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
No split
Adaptation
None; published models or precomputed scores
Scoring implementation
Sensitivity at the tool threshold calling 10% of the 500,000-SNV background set

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
None; published models or precomputed scores
Context-only references
Benchmarking splice variant prediction algorithms using massively parallel splicing assays

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 24:294, published 2023-12-21; PMC10734170 full-text XML
Retrieved: 2026-10-09T20:49:26Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 5aceff067af63ab59400ade7dd7db563a16fc7f4d6db6fa55d5b34689f7a0769

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
None; published models or precomputed scores
Context-only references
Smith and Kitzman 2023, Additional file 3 (Table S2)

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2023_3144_MOESM3_ESM.xlsx inside the Europe PMC supplementaryFiles zip for PMC10734170
Retrieved: 2026-10-09T20:49:34Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: c5ed8dc1488f87a1aff766c0ed4c8b3faab148259ca6e6f28e729b9a57a700fa

Hash scope: SHA-256 of the MOESM3 xlsx member (zip SHA-256 e06758da73eda5d4ba9c61361514ed2d84573bf50df5bf8036102389e019d525; Europe PMC assembles the zip per request).

Inspected artifact

attributes.comparison.aggregation
Pooled over the dataset's variants, by variant class
Context-only references
Benchmarking splice variant prediction algorithms using massively parallel splicing assays

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 24:294, published 2023-12-21; PMC10734170 full-text XML
Retrieved: 2026-10-09T20:49:26Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 5aceff067af63ab59400ade7dd7db563a16fc7f4d6db6fa55d5b34689f7a0769

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Pooled over the dataset's variants, by variant class
Context-only references
Smith and Kitzman 2023, Additional file 3 (Table S2)

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2023_3144_MOESM3_ESM.xlsx inside the Europe PMC supplementaryFiles zip for PMC10734170
Retrieved: 2026-10-09T20:49:34Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: c5ed8dc1488f87a1aff766c0ed4c8b3faab148259ca6e6f28e729b9a57a700fa

Hash scope: SHA-256 of the MOESM3 xlsx member (zip SHA-256 e06758da73eda5d4ba9c61361514ed2d84573bf50df5bf8036102389e019d525; Europe PMC assembles the zip per request).

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Benchmarking splice variant prediction algorithms using massively parallel splicing assays

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 24:294, published 2023-12-21; PMC10734170 full-text XML
Retrieved: 2026-10-09T20:49:26Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 5aceff067af63ab59400ade7dd7db563a16fc7f4d6db6fa55d5b34689f7a0769

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Smith and Kitzman 2023, Additional file 3 (Table S2)

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2023_3144_MOESM3_ESM.xlsx inside the Europe PMC supplementaryFiles zip for PMC10734170
Retrieved: 2026-10-09T20:49:34Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: c5ed8dc1488f87a1aff766c0ed4c8b3faab148259ca6e6f28e729b9a57a700fa

Hash scope: SHA-256 of the MOESM3 xlsx member (zip SHA-256 e06758da73eda5d4ba9c61361514ed2d84573bf50df5bf8036102389e019d525; Europe PMC assembles the zip per request).

Inspected artifact

attributes.comparison.dataset_version
Smith and Kitzman benchmark set (Additional file 2)
Context-only references
Benchmarking splice variant prediction algorithms using massively parallel splicing assays

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 24:294, published 2023-12-21; PMC10734170 full-text XML
Retrieved: 2026-10-09T20:49:26Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 5aceff067af63ab59400ade7dd7db563a16fc7f4d6db6fa55d5b34689f7a0769

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Smith and Kitzman benchmark set (Additional file 2)
Context-only references
Smith and Kitzman 2023, Additional file 3 (Table S2)

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2023_3144_MOESM3_ESM.xlsx inside the Europe PMC supplementaryFiles zip for PMC10734170
Retrieved: 2026-10-09T20:49:34Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: c5ed8dc1488f87a1aff766c0ed4c8b3faab148259ca6e6f28e729b9a57a700fa

Hash scope: SHA-256 of the MOESM3 xlsx member (zip SHA-256 e06758da73eda5d4ba9c61361514ed2d84573bf50df5bf8036102389e019d525; Europe PMC assembles the zip per request).

Inspected artifact

attributes.comparison.inputs
SNV in genomic context with one MANE Select canonical transcript (SQUIRLS: default hg19 Ensembl)
Context-only references
Benchmarking splice variant prediction algorithms using massively parallel splicing assays

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 24:294, published 2023-12-21; PMC10734170 full-text XML
Retrieved: 2026-10-09T20:49:26Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 5aceff067af63ab59400ade7dd7db563a16fc7f4d6db6fa55d5b34689f7a0769

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
SNV in genomic context with one MANE Select canonical transcript (SQUIRLS: default hg19 Ensembl)
Context-only references
Smith and Kitzman 2023, Additional file 3 (Table S2)

Original source ↗

Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2023_3144_MOESM3_ESM.xlsx inside the Europe PMC supplementaryFiles zip for PMC10734170
Retrieved: 2026-10-09T20:49:34Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: c5ed8dc1488f87a1aff766c0ed4c8b3faab148259ca6e6f28e729b9a57a700fa

Hash scope: SHA-256 of the MOESM3 xlsx member (zip SHA-256 e06758da73eda5d4ba9c61361514ed2d84573bf50df5bf8036102389e019d525; Europe PMC assembles the zip per request).

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: splicing-follow-up-20261009-eval-smith2023-pou1f1-exon2-mpsa-spanr-spidex

areas
dna-genomes
contexts
research
origin
independent_paper
protocol
splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10
version
Primary source as retrieved 2026-10-09
comparison
dataset version: Smith and Kitzman benchmark set (Additional file 2); split: No split; population: Saturation minigene MPSA of POU1F1 exon 2 (alpha and beta acceptors).; inputs: SNV in genomic context with one MANE Select canonical transcript (SQUIRLS: default hg19 Ensembl); adaptation: None; published models or precomputed scores; metric implementation: Sensitivity at the tool threshold calling 10% of the 500,000-SNV background set; aggregation: Pooled over the dataset's variants, by variant class; budget: Not reported; protocol id: splicing-follow-up-20261009-protocol-smith2023-pou1f1-exon2-mpsa-tn10
source locator
Additional file 3 sheet 'Sensitivity 10% SDV', column E ('POU1F1'), rows for SPANR
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