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1 evaluation · 4 results. Different protocols are not a single leaderboard.
Protocol: Splice-altering variant classification, Riepe et al. functional splice assay variants (213 variants, ABCA4 and MYBPC3) (Fortier et al. Table 2) · Dataset: Riepe et al. functional splice assay variants (213 variants, ABCA4 and MYBPC3)
Sorted by Balanced accuracy (threshold optimised per gene and algorithm for maximum accuracy (upper bound)) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Balanced accuracy (threshold optimised per gene and algorithm for maximum accuracy (upper bound)) | F1 (threshold optimised per gene and algorithm for maximum accuracy (upper bound)) | Recall (threshold optimised per gene and algorithm for maximum accuracy (upper bound)) | Specificity (threshold optimised per gene and algorithm for maximum accuracy (upper bound)) |
|---|---|---|---|---|
| Legacy Ensemble (Fortier et al. 2026)Evaluation | 0.659 | 0.609 | 0.5 | 0.817 |
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18 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation threshold optimised per gene and algorithm for maximum accuracy (upper bound) Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation Whole dataset Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget Not reported Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version As assembled by Fortier et al. 2026 Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs Variant with genomic sequence context (VCF) Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation Sensitivity, specificity, F1 = 2TP/(2TP+FP+FN), balanced accuracy = mean of sensitivity and specificity (Equations 1 to 4) Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population 152 ABCA4 and 61 MYBPC3 variants from the functional splice assays of Riepe et al. (2021); 81 ABCA4 variants are deep intronic; none alter canonical splice-site dinucleotides Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id rna-splicing-20261011-fortier2026-protocol-riepe Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Whole set Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Origin author_reported Context-only references | Analyzing the performance of deep learning splice prediction algorithms (Fortier, Rudy and Scherer, PLOS One 2026) Table 2 row 'Legacy Ensemble' Version: PLOS One 21(5):e0348885, published 2026-05-13; PMC13170886 full-text XML | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: rna-splicing-20261011-fortier2026-eval-riepe-legacy-ensemble