rewirebio.iobenchmarks
Evaluation

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 83 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
80.8% Percent agreement (overall, 104 fusion detection results in 101 patients)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods' paragraph 1: 'The overall concordance rate between RNA-seq and conventional diagnostics was 80.8%.'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
21.4% False positive rate (overall, 56 fusion-negative results by conventional diagnostics; RNA-seq-only fusions counted as errors, though the authors describe several as well-known recurrent fusions and confirmed one by RT-PCR and Sanger sequencing)
percent · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods' paragraph 1: 'among 56 fusion-negative results based on conventional diagnostics, RNA-seq helped identify 12 fusion genes (21.4%, reflecting 1 – specificity)'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
83.3% Recall (overall, 48 fusions detected by conventional diagnostics)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods' paragraph 1: 'Of the 48 fusion genes detected using conventional diagnostics, RNA-seq helped identify 40 and missed eight (83.3% sensitivity)'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
86.4% Recall (AML patients, fusions detected by conventional diagnostics)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Discussion paragraph 2: 'with a fusion detection sensitivity of 83.3%, comparable across AML (86.4%) and B-ALL (87.0%)'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
87% Recall (B-ALL patients, fusions detected by conventional diagnostics)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Discussion paragraph 2: 'with a fusion detection sensitivity of 83.3%, comparable across AML (86.4%) and B-ALL (87.0%)'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
81% Percent agreement (BCR::ABL1 (conventional-positive; AML, B-ALL))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'BCR::ABL1', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
16 Count (BCR::ABL1 (conventional-positive; AML, B-ALL))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'BCR::ABL1', column 'Number of fusions detected using conventional diagnostics'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
13 True positives (BCR::ABL1 (conventional-positive; AML, B-ALL))
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'BCR::ABL1', column 'Number of fusions detected using RNA-seq'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
100% Percent agreement (CBFB::MYH11 (conventional-positive; AML))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'CBFB::MYH11', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
6 Count (CBFB::MYH11 (conventional-positive; AML))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'CBFB::MYH11', column 'Number of fusions detected using conventional diagnostics'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
6 True positives (CBFB::MYH11 (conventional-positive; AML))
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'CBFB::MYH11', column 'Number of fusions detected using RNA-seq'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
100% Percent agreement (DEK::NUP214 (conventional-positive; AML))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'DEK::NUP214', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
1 Count (DEK::NUP214 (conventional-positive; AML))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'DEK::NUP214', column 'Number of fusions detected using conventional diagnostics'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
1 True positives (DEK::NUP214 (conventional-positive; AML))
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'DEK::NUP214', column 'Number of fusions detected using RNA-seq'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
0% Percent agreement (ETV6::NCOA2 (RNA-seq only; MPAL))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'ETV6::NCOA2', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
0 Count (ETV6::NCOA2 (RNA-seq only; MPAL))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'ETV6::NCOA2', column 'Number of fusions detected using conventional diagnostics'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
1 Count (ETV6::NCOA2 (RNA-seq only; MPAL))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'ETV6::NCOA2', column 'Number of fusions detected using RNA-seq'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
67% Percent agreement (ETV6::RUNX1 (conventional-positive; B-ALL))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'ETV6::RUNX1', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
3 Count (ETV6::RUNX1 (conventional-positive; B-ALL))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'ETV6::RUNX1', column 'Number of fusions detected using conventional diagnostics'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
2 True positives (ETV6::RUNX1 (conventional-positive; B-ALL))
count · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using conventional diagnostics', row 'ETV6::RUNX1', column 'Number of fusions detected using RNA-seq'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
0% Percent agreement (FUS::ZNF362 (RNA-seq only; B-ALL))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'FUS::ZNF362', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
0 Count (FUS::ZNF362 (RNA-seq only; B-ALL))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'FUS::ZNF362', column 'Number of fusions detected using conventional diagnostics'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
1 Count (FUS::ZNF362 (RNA-seq only; B-ALL))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'FUS::ZNF362', column 'Number of fusions detected using RNA-seq'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
0% Percent agreement (HNRNPH1::ERG (RNA-seq only; AML))
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'HNRNPH1::ERG', column 'Concordance, %'
Configuration: STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)Protocol: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset: Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
0 Count (HNRNPH1::ERG (RNA-seq only; AML))
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics

Aggregation: Not reported

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Table 2, section 'Fusion genes detected using RNA-seq only', row 'HNRNPH1::ERG', column 'Number of fusions detected using conventional diagnostics'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)

Configuration
STAR 2.7.7a and Arriba v2.4.0 high-confidence calls with manual IGV review (Kim et al. 2026)
Protocol
Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Dataset
Samsung Medical Center acute leukaemia bone-marrow whole RNA-seq, 101 patients (2022-2023)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics
dataset version
Not reported
split
Retrospective cohort
population
101 patients with acute leukaemia
inputs
Bone-marrow whole RNA-seq, 2 x 150 bp
adaptation
Not reported
metric implementation
Fusion-level agreement with conventional diagnostics
aggregation
Pooled over patients; per-fusion counts in Table 2
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Retrospective cohort
Adaptation
Not reported
Scoring implementation
Fusion-level agreement with conventional diagnostics

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Not reported
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Pooled over patients; per-fusion counts in Table 2
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: inputs
Bone-marrow whole RNA-seq, 2 x 150 bp
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: metric implementation
Fusion-level agreement with conventional diagnostics
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: population
101 patients with acute leukaemia
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: protocol id
rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: split
Retrospective cohort
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Origin
independent_paper
Context-only references
Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia

Original source ↗

Table 2; Results paragraph 1 of the performance section

Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML
Retrieved: 2026-10-11T21:37:42Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: 4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: rna-fusion-leukaemia-20261011-eval-arriba-conventional-diagnostics

areas
rna-transcriptomes
contexts
clinical_research
origin
independent_paper
protocol
rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics
version
Primary source as retrieved 2026-10-11
comparison
protocol id: rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics; dataset version: Not reported; split: Retrospective cohort; population: 101 patients with acute leukaemia; inputs: Bone-marrow whole RNA-seq, 2 x 150 bp; adaptation: Not reported; metric implementation: Fusion-level agreement with conventional diagnostics; aggregation: Pooled over patients; per-fusion counts in Table 2; budget: Not reported
source locator
Table 2; Results paragraph 1 of the performance section
missing metadata
comparison.adaptation: reason: inapplicable; comparison.budget: reason: unreported; comparison.dataset version: reason: unreported
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