rewirebio.iobenchmarks
Evaluation

UniRep on ProteinGym ZS-SUB-MCC: Zero-shot substitutions, MCC

ProteinGym evaluation of UniRep on Zero-shot substitutions, MCC, scored with MCC.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: UniRepTask: ProteinGym ZS-SUB-MCC: Zero-shot substitutions, MCC
Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)
0.147 MCC
unitless · higher

Uncertainty: Not yet extracted

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

UniRep on ProteinGym ZS-SUB-MCC: Zero-shot substitutions, MCC

Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes.

Aggregation: Not reported

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes.

Configuration
UniRep
Task
ProteinGym ZS-SUB-MCC: Zero-shot substitutions, MCC
Dataset subset
ProteinGym substitution DMS assays (ProteinGym split)
origin
Independent external evaluation
configuration
Not reported
protocol id
proteingym-task-zs-sub-mcc
metric implementation
MCC

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Not reported
Adaptation
Not reported
Scoring implementation
MCC

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

11 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Comparison: metric implementation
MCC
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: protocol id
proteingym-task-zs-sub-mcc
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Evaluation group id
evaluation-group-proteingym-table-2-zero-shot-substitutions-unirep
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.evaluation_group_id

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Evaluation group name
UniRep · zero-shot substitutions
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.evaluation_group_name

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Protocol
Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes.
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.protocol

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Source location
Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.source_locator

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Description
ProteinGym evaluation of UniRep on Zero-shot substitutions, MCC, scored with MCC.
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: description

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Relationship: assessment
proteingym-task-zs-sub-mcc
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: links:assessment:proteingym-task-zs-sub-mcc

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Relationship: data
proteingym-dataset-proteingym-substitution-dms-assays
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: links:data:proteingym-dataset-proteingym-substitution-dms-assays

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Relationship: system
proteingym-method-unirep
Context-only references
ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design

Original source ↗

Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.522924+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: links:system:proteingym-method-unirep

Source artifact SHA-256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: proteingym-evaluation-unirep-zs-sub-mcc

areas
proteins-complexes
tasks
Zero-shot substitutions, MCC
origin
independent_paper
protocol
Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes.
comparison
protocol id: proteingym-task-zs-sub-mcc; metric implementation: MCC
missing metadata
budget: reason: unreported; checkpoint revision: reason: unreported; seeds: reason: unreported; split manifest: reason: unextracted
source locator
Table 2, row(Protein UniRep), column(Zero-shot substitutions, MCC)
evaluation group id
evaluation-group-proteingym-table-2-zero-shot-substitutions-unirep
evaluation group name
UniRep · zero-shot substitutions
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