rewirebio.iobenchmarks
Evaluation

Mean baseline on PertEval-scFM Norman single-gene (2,000 HVGs) AUSPC

PertEval-scFM evaluation of the Mean baseline (context-mean, no-perturbation-specific-effect null model) on the Norman single-gene, 2,000-HVG, SPECTRA-sparsification AUSPC protocol.

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Release 2026-10-07-1448159e6a81 · Evidence verified: Not verified

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Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Mean baseline (context mean, no perturbation-specific effect)Protocol: PertEval-scFM Norman single-gene (2,000 HVGs) AUSPC across SPECTRA sparsification splits
Dataset subset: Norman et al. 2019 single-gene perturbations, K562, top 2,000 HVGs (PertEval-scFM Table 1)
4.612 ± 0.317 AUSPC
10^-2 (printed column header units) · lower

Uncertainty: type: author_reported_propagated_standard_error; reported spread: 0.317; note: The source describes this quantity as a standard error (main-text Figure 2 caption: 'Average AUSPC (down-arrow) across sparsification probabilities for each model with standard error bars') and separately gives its own propagation formula (Appendix F.2, Eqs. F3-F5): AUSPC's uncertainty is derived from each split's own MSE uncertainty via the trapezoidal integral's partial derivatives (sigma^2 = sum_i (d/2)^2 * sigma_phi_i^2, where d=0.1 is the fixed sparsification step size). These two author statements describe the same quantity and are not in conflict: a propagated quantity can correctly be reported as a standard error. This is recorded as the author's own reported, propagated uncertainty; the F3-F5 derivation is the authors' own formula and its mathematical correctness has not been independently validated here. It must not be read as an independently resampled model-seed standard deviation or a confidence interval. The underlying per-split uncertainty is attributed by the source to triplicate experiments per model (Appendix I, Figure I1 caption: 'Experiments were carried out in triplicate for each model'), not to the main-text Figure 2 region. Figure I1's own caption separately states '8 train-test splits of increasing difficulty' for this same Norman single-gene evaluation, while Table 1 prints seven S-columns (S0.1-S0.7) and Appendix F.2 describes the sparsification probabilities as spanning 0.1 to 0.7. This 7-vs-8 discrepancy between the Figure I1 caption and the Table 1 / F.2 grid is preserved exactly as printed, not resolved; it must not be read as establishing an eighth Table 1 column or a confirmed n_runs=7, and no significance claim is made from any overlapping error bars.

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Mean baseline on PertEval-scFM Norman single-gene (2,000 HVGs) AUSPC

Trapezoidal-rule AUSPC of MSE, scored on the perturbation-effect delta=P-Xc (Eq. 5), across seven SPECTRA sparsification splits (s=0.1..0.7), Norman single-gene, 2,000 HVGs.

Aggregation: Not reported

PertEval-scFM (Wenteler et al., ICML 2025), full text · Table 1, Norman single-gene section, row Mean baseline, column AUSPC (10^-2).

Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.

Evaluation procedure

Trapezoidal-rule AUSPC of MSE, scored on the perturbation-effect delta=P-Xc (Eq. 5), across seven SPECTRA sparsification splits (s=0.1..0.7), Norman single-gene, 2,000 HVGs.

Configuration
Mean baseline (context mean, no perturbation-specific effect)
Protocol
PertEval-scFM Norman single-gene (2,000 HVGs) AUSPC across SPECTRA sparsification splits
Dataset subset
Norman et al. 2019 single-gene perturbations, K562, top 2,000 HVGs (PertEval-scFM Table 1)
origin
Author-reported evaluation
configuration
Not reported
protocol id
perteval-scfm-2025-protocol-norman-single-2000hvg-auspc
metric implementation
AUSPC (trapezoidal-rule integral of MSE across seven SPECTRA sparsification-probability train-test splits, s=0.1..0.7; Appendix F.2 Eq. F2)

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Not reported
Adaptation
Not reported
Scoring implementation
AUSPC (trapezoidal-rule integral of MSE across seven SPECTRA sparsification-probability train-test splits, s=0.1..0.7; Appendix F.2 Eq. F2)

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

14 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-07-1448159e6a81
Property and statementOriginal source and locationReview and provenance
attributes.adaptation
Context-mean null predictor (Section 2.2, 'Mean baseline'); no learned parameters.
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.adaptation

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.metric_implementation
AUSPC (trapezoidal-rule integral of MSE across seven SPECTRA sparsification-probability train-test splits, s=0.1..0.7; Appendix F.2 Eq. F2)
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.protocol_id
perteval-scfm-2025-protocol-norman-single-2000hvg-auspc
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.evidence_overlap
Independent of the GEARS Supplementary Table 6 catalogue entries for this use case. Serves as this protocol's own negative/no-effect control, distinct from Table 6's own 'No Perturb' control.
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.evidence_overlap

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.origin
author_reported
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.origin

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.protocol
Trapezoidal-rule AUSPC of MSE, scored on the perturbation-effect delta=P-Xc (Eq. 5), across seven SPECTRA sparsification splits (s=0.1..0.7), Norman single-gene, 2,000 HVGs.
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.protocol

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.published_score_reproduction
false
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.published_score_reproduction

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.source_locator
Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.source_locator

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.suite_complete
false
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.suite_complete

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

description
PertEval-scFM evaluation of the Mean baseline (context-mean, no-perturbation-specific-effect null model) on the Norman single-gene, 2,000-HVG, SPECTRA-sparsification AUSPC protocol.
Context-only references
PertEval-scFM (Wenteler et al., ICML 2025), full text

Original source ↗

Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).

Version: PMLR v267 wenteler25a (as served by the PMLR-affiliated mlresearch/v267 GitHub mirror; ETag "ed9f0fe44cf6edc939ee6950d024f65dcd8dd6f16414bd9f5297cda9395d6e58" at retrieval)
Retrieved: 2026-10-07T11:39:51Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: description

Source artifact SHA-256: c116a153872645d5c91b9ee836df3945cd8ffd02a6e736f58f854c4b70978bcc

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

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Release 2026-10-07-1448159e6a81 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: perteval-scfm-2025-evaluation-mean-baseline

areas
cells-spatial-multiomics
tasks
Norman single-gene perturbation effect prediction, 2,000 HVGs, SPECTRA distribution shift
origin
author_reported
protocol
Trapezoidal-rule AUSPC of MSE, scored on the perturbation-effect delta=P-Xc (Eq. 5), across seven SPECTRA sparsification splits (s=0.1..0.7), Norman single-gene, 2,000 HVGs.
missing metadata
checkpoint revision: not applicable: the Mean baseline has no learned parameters (a population statistic only), so no trained artifact or checkpoint exists for it.; seeds: unreported beyond 'triplicate' language; split manifest: unextracted beyond the SPECTRA sparsification-probability mechanism itself
source locator
Table 1, row Mean baseline, Norman single-gene section, column AUSPC (10^-2).
adaptation
Context-mean null predictor (Section 2.2, 'Mean baseline'); no learned parameters.
evidence overlap
Independent of the GEARS Supplementary Table 6 catalogue entries for this use case. Serves as this protocol's own negative/no-effect control, distinct from Table 6's own 'No Perturb' control.
published score reproduction
false
suite complete
false
comparison
protocol id: perteval-scfm-2025-protocol-norman-single-2000hvg-auspc; metric implementation: AUSPC (trapezoidal-rule integral of MSE across seven SPECTRA sparsification-probability train-test splits, s=0.1..0.7; Appendix F.2 Eq. F2)
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