rewirebio.iobenchmarks
Evaluation

ESM2 35M: Held-out human-versus-virus protein classification

Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.

Evaluation results

1 evaluation · 4 results. Different protocols are not a single leaderboard.

Protocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification) · Dataset: human and viral proteins

Sorted by Accuracy (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationAccuracyAUROCPrecisionRecall
ESM2 35MEvaluation95.8%98.793.8%93.9%
All 4 result rows with coverage, uncertainty and sources
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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ESM2 35MProtocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification)
Dataset: human and viral proteins
98.7 AUROC
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2 35M: Held-out human-versus-virus protein classification

Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.

Aggregation: Not reported

Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 35M, column AUC (%); XML row5 column2
Configuration: ESM2 35MProtocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification)
Dataset: human and viral proteins
93.8% Precision
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2 35M: Held-out human-versus-virus protein classification

Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.

Aggregation: Not reported

Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 35M, column Prec.; XML row5 column4
Configuration: ESM2 35MProtocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification)
Dataset: human and viral proteins
93.9% Recall
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2 35M: Held-out human-versus-virus protein classification

Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.

Aggregation: Not reported

Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 35M, column Recall; XML row5 column5
Configuration: ESM2 35MProtocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification)
Dataset: human and viral proteins
95.8% Accuracy
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2 35M: Held-out human-versus-virus protein classification

Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.

Aggregation: Not reported

Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 35M, column Accur.; XML row5 column3

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.

Configuration
ESM2 35M
Protocol
Held-out human-versus-virus protein classification (human-versus-viral protein classification)
Dataset
human and viral proteins
origin
Author-reported evaluation
configuration
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
protocol id
paper-protocol-1352834b9391c1dacb
dataset version
Not reported
split
UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.
subset
Held-out human-versus-virus protein classification
population
Not reported
aggregation
Precision and recall macro-averaged over classes; AUROC and log-loss computed with scikit-learn.
inputs
Not reported
adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
budget
Not reported
metric implementation
Not reported

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split
UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.
Adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: aggregation
Precision and recall macro-averaged over classes; AUROC and log-loss computed with scikit-learn.
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: budget
Not reported
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: inputs
Not reported
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: metric implementation
Not reported
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: population
Not reported
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: protocol id
paper-protocol-1352834b9391c1dacb
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: split
UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: subset
Held-out human-versus-virus protein classification
Context-only references
Protein Language Models Expose Viral Immune Mimicry

Original source ↗

Table 1: AUC (%), Held-out human-versus-virus protein classification

Version: version of record
Retrieved: 2026-09-17T07:56:17.192528+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.subset

Source artifact SHA-256: 15250af2f75f70e2b6a3725d00bc7e276ed9d2d4a54f0ae9d6eaabf6be13e4a1

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: needs review

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: paper-evaluation-a37f0b2123458018c1

areas
proteins-complexes
tasks
human-versus-viral protein classification
origin
author_reported
protocol
Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.
version
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
comparison
protocol id: paper-protocol-1352834b9391c1dacb; dataset version: Not reported; split: UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1.; subset: Held-out human-versus-virus protein classification; population: Not reported; aggregation: Precision and recall macro-averaged over classes; AUROC and log-loss computed with scikit-learn.; inputs: Not reported; adaptation: Paper-specific evaluated pipeline; exact checkpoint not inferred from label; budget: Not reported; metric implementation: Not reported
source locator
Table 1: AUC (%), Held-out human-versus-virus protein classification
missing metadata
budget: reason: unreported; checkpoint revision: reason: unextracted; split manifest: reason: unextracted
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