rewirebio.iobenchmarks
Evaluation

ESM2_AMPS: Pan_dataset five-fold PPI cross-validation

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Evaluation results

1 evaluation · 5 results. Different protocols are not a single leaderboard.

Protocol: Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction) · Dataset: Pan_dataset five-fold PPI cross-validation

Sorted by Accuracy (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationAccuracyAUROCF1MCCRecall
ESM2_AMPSEvaluation0.9780.9950.9780.9550.971
All 5 result rows with coverage, uncertainty and sources
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Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ESM2_AMPSProtocol: Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction)
Dataset: Pan_dataset five-fold PPI cross-validation
0.995 AUROC
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2_AMPS: Pan_dataset five-fold PPI cross-validation

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Aggregation: Not reported

ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery · Table 2, row ESM2_AMPS, column AUC; XML row2 column5
Configuration: ESM2_AMPSProtocol: Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction)
Dataset: Pan_dataset five-fold PPI cross-validation
0.955 MCC
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2_AMPS: Pan_dataset five-fold PPI cross-validation

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Aggregation: Not reported

ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery · Table 2, row ESM2_AMPS, column MCC; XML row2 column6
Configuration: ESM2_AMPSProtocol: Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction)
Dataset: Pan_dataset five-fold PPI cross-validation
0.978 Accuracy
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2_AMPS: Pan_dataset five-fold PPI cross-validation

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Aggregation: Not reported

ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery · Table 2, row ESM2_AMPS, column Accuracy; XML row2 column2
Configuration: ESM2_AMPSProtocol: Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction)
Dataset: Pan_dataset five-fold PPI cross-validation
0.978 F1
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2_AMPS: Pan_dataset five-fold PPI cross-validation

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Aggregation: Not reported

ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery · Table 2, row ESM2_AMPS, column F1 Score; XML row2 column4
Configuration: ESM2_AMPSProtocol: Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction)
Dataset: Pan_dataset five-fold PPI cross-validation
0.971 Recall
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2_AMPS: Pan_dataset five-fold PPI cross-validation

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Aggregation: Not reported

ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery · Table 2, row ESM2_AMPS, column Recall; XML row2 column3

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

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  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

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  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

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No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.

Configuration
ESM2_AMPS
Protocol
Pan_dataset five-fold PPI cross-validation (protein-protein interaction prediction)
Dataset
Pan_dataset five-fold PPI cross-validation
origin
Author-reported evaluation
configuration
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
protocol id
paper-protocol-be1c9eab950fb814ec
dataset version
Not reported
split
Pan_dataset; Table 2 five-fold cross-validation.
subset
Pan_dataset five-fold PPI cross-validation
population
Not reported
aggregation
Not reported
inputs
Not reported
adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
budget
Not reported
metric implementation
Not reported

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Pan_dataset; Table 2 five-fold cross-validation.
Adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: budget
Not reported
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: inputs
Not reported
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: metric implementation
Not reported
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: population
Not reported
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: protocol id
paper-protocol-be1c9eab950fb814ec
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: split
Pan_dataset; Table 2 five-fold cross-validation.
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: subset
Pan_dataset five-fold PPI cross-validation
Context-only references
ESM2_AMP: an interpretable framework for protein–protein interactions prediction and biological mechanism discovery

Original source ↗

Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation

Version: version of record
Retrieved: 2026-09-17T07:56:12.275470+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.subset

Source artifact SHA-256: 8e7ad6efb72ca28d73037cdf465b0e62f99cd6d0ee4ca9eaf96a4c48da22fd6c

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: needs review

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: paper-evaluation-988f9801136204e31b

areas
molecular-interactions
tasks
protein-protein interaction prediction
origin
author_reported
protocol
ESM 2_AMPS, ESM 2_AMP_CSE and ESM 2_DPM evaluated as complete PPI pipelines. Pan_dataset; Table 2 five-fold cross-validation.
version
Paper-specific evaluated pipeline; exact checkpoint not inferred from label
comparison
protocol id: paper-protocol-be1c9eab950fb814ec; dataset version: Not reported; split: Pan_dataset; Table 2 five-fold cross-validation.; subset: Pan_dataset five-fold PPI cross-validation; population: Not reported; aggregation: Not reported; inputs: Not reported; adaptation: Paper-specific evaluated pipeline; exact checkpoint not inferred from label; budget: Not reported; metric implementation: Not reported
source locator
Table 2: Accuracy, Pan_dataset five-fold PPI cross-validation
missing metadata
budget: reason: unreported; checkpoint revision: reason: unextracted; split manifest: reason: unextracted
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