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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Chroma (Scaffold-Lab unconditional generation) | Protocol: Scaffold-Lab unconditional generation: Novelty(↓) Dataset: Scaffold-Lab generated backbones (100 per length group) | 0.742 TM score (novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing; length 1000) unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceChroma Novelty(↓) on Scaffold-Lab unconditional generation, length 1000 lit-structure-20261011-scaffoldlab-protocol-novelty Aggregation: Not reported Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework · Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' |
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Scaffold-Lab unconditional generation: Novelty(↓)
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18 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation None; methods run with their released weights inside the Scaffold-Lab pipeline Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation Mean within the length Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget 100 backbones per length, 10 designed sequences per backbone Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version Not reported Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | missing or unspecified No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs Target backbone length only (unconditional generation) Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation novelty as the pdb-TM of designable backbones against the PDB (lower is more novel); group mean without data preprocessing Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population 100 generated backbones per length Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id lit-structure-20261011-scaffoldlab-protocol-novelty Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Long group, length 1000 Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Origin independent_paper Context-only references | Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework Table 3, row 'Long' / 'Chroma' / length 1000, column 'Novelty(↓)' Version: Version of record, PLoS Computational Biology 2026 (PMC13225634 JATS full text) | not individually reviewed No individual claim review recorded independent paper Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-23-5347695500ed · Record review: source checked
Stable ID: lit-structure-20261011-scaffoldlab-eval-novelty-chroma-long-1000