rewirebio.iobenchmarks
Evaluation

scVI sampling on Sun et al. 2026 within-cell-line DE classification, K562

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: scVI perturbation model, sampled output (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: K562 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
4.09% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scVI sampling on Sun et al. 2026 within-cell-line DE classification, K562

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'scVI sampling', column 'K562'

Source checking is not independent reproduction. Release 2026-10-23-5347695500ed.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-23-5347695500ed · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Sun et al. 2026 unseen-perturbation DE classification (within cell line)

Configuration
scVI perturbation model, sampled output (Sun et al. 2026)
Protocol
Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset
K562 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
lit-cells-networks-20261011-sun2026de-protocol-within-cell-line
dataset version
Not reported
split
60/40 split by perturbation
population
Not reported
inputs
Training perturbations with observed expression or DE labels, control-cell expression, and a perturbation representation (GenePT, LLM-derived or learned embedding) where the method uses one
adaptation
Trained per split
metric implementation
Wilcoxon rank-sum DE calls, BH-adjusted p < 0.01, on predicted and observed expression
aggregation
Single cell line
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
60/40 split by perturbation
Adaptation
Trained per split
Scoring implementation
Wilcoxon rank-sum DE calls, BH-adjusted p < 0.01, on predicted and observed expression

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-23-5347695500ed
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Trained per split
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: aggregation
Single cell line
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: budget
Not reported
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

missing or unspecified

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

missing or unspecified

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: inputs
Training perturbations with observed expression or DE labels, control-cell expression, and a perturbation representation (GenePT, LLM-derived or learned embedding) where the method uses one
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: metric implementation
Wilcoxon rank-sum DE calls, BH-adjusted p < 0.01, on predicted and observed expression
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: population
Not reported
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

missing or unspecified

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: protocol id
lit-cells-networks-20261011-sun2026de-protocol-within-cell-line
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Comparison: split
60/40 split by perturbation
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Origin
independent_paper
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Table 1, row 'scVI sampling'

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.origin

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-23-5347695500ed · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-cells-networks-20261011-sun2026de-eval-within-k562-scvi-sampling

areas
single-cell
contexts
research
origin
independent_paper
protocol
lit-cells-networks-20261011-sun2026de-protocol-within-cell-line
version
Primary source as retrieved 2026-10-11
comparison
protocol id: lit-cells-networks-20261011-sun2026de-protocol-within-cell-line; dataset version: Not reported; split: 60/40 split by perturbation; population: Not reported; inputs: Training perturbations with observed expression or DE labels, control-cell expression, and a perturbation representation (GenePT, LLM-derived or learned embedding) where the method uses one; adaptation: Trained per split; metric implementation: Wilcoxon rank-sum DE calls, BH-adjusted p < 0.01, on predicted and observed expression; aggregation: Single cell line; budget: Not reported
source locator
Table 1, row 'scVI sampling'
missing metadata
comparison.budget: reason: unreported; comparison.dataset version: reason: unreported; comparison.population: reason: unreported
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