ESMFold2 Runs N’ Poses reported comparison evaluation of ESMFold2 (single sequence, 20 loops) on Runs N’ Poses ligand pass rate (single sequence), scored with Ligand pass rate.
1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ESMFold2 (single sequence, 20 loops) | Protocol: ESMFold2 Runs N’ Poses reported comparison single-sequence: Runs N’ Poses ligand pass rate (single sequence) Dataset subset: Runs N’ Poses complete-case intersection: 2,573 scored ligands (ESMFold2 Runs N’ Poses reported comparison split) | 66% Ligand pass rate percent · higher Uncertainty: Not yet extracted Coverage: 2573 ligands scored (Complete-case intersection; source 2600 systems is not a ligand denominator.) | Author-reported evaluation · Source checkedMethods, coverage and sourceRuns N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate. Aggregation: Not reported ESMFold2 primary paper v1, Figure 2C Runs N’ Poses · PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label |
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Runs N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate.
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14 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Adaptation Author-evaluated co-folding using the named released model; no new fine-tuning inferred. Conditioning and inference budgets follow Figure 2C and Appendix A.2.10. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation Ligand pass rate Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id esmfold2-2026-runs-n-poses-task-single-sequence Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Count unit ligands Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Evidence overlap One receptor-ligand comparison reported at two conditioning modes and multiple inference settings; not independent benchmark replications. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Origin author_reported Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Protocol Runs N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scored count 2573 Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description ESMFold2 Runs N’ Poses reported comparison evaluation of ESMFold2 (single sequence, 20 loops) on Runs N’ Poses ligand pass rate (single sequence), scored with Ligand pass rate. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 4 from left (ESMFold2 (single sequence, 20 loops)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
Stable ID: esmfold2-2026-runs-n-poses-evaluation-esmfold2-single-sequence-20-loops-single-sequence