ESMFold2 Runs N’ Poses reported comparison evaluation of Chai-1 (single sequence) on Runs N’ Poses ligand pass rate (single sequence), scored with Ligand pass rate.
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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Chai-1 (single sequence) | Protocol: ESMFold2 Runs N’ Poses reported comparison single-sequence: Runs N’ Poses ligand pass rate (single sequence) Dataset subset: Runs N’ Poses complete-case intersection: 2,573 scored ligands (ESMFold2 Runs N’ Poses reported comparison split) | 51% ligand_pass_rate percent · higher Uncertainty: Not reported Coverage: unit: ligands; scored: 2573; eligible: unreported; note: Complete-case intersection; source 2600 systems is not a ligand denominator. | Author-reported evaluation · Source checkedMethods, coverage and sourceRuns N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate. Aggregation: Not reported ESMFold2 primary paper v1, Figure 2C Runs N’ Poses · PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label |
Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.
Runs N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate.
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16 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.adaptation Author-evaluated co-folding using the named released model; no new fine-tuning inferred. Conditioning and inference budgets follow Figure 2C and Appendix A.2.10. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.metric_implementation Ligand pass rate Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.protocol_id esmfold2-2026-runs-n-poses-task-single-sequence Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.count_unit ligands Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.evidence_overlap One receptor-ligand comparison reported at two conditioning modes and multiple inference settings; not independent benchmark replications. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.origin author_reported Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.protocol Runs N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate. Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.published_score_reproduction false Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.scored_count 2573 Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.source_locator PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Context-only references | ESMFold2 primary paper v1, Figure 2C Runs N’ Poses PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), single-sequence block, bar 1 from left (Chai-1 (single sequence)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
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Release 2026-09-29-06401fd5b220 · Record review: source checked
Stable ID: esmfold2-2026-runs-n-poses-evaluation-chai-1-single-sequence-single-sequence