rewirebio.iobenchmarks
Dataset subset

HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)

HepG2 essential-gene screen, normalised to 10,000 counts and log1p; perturbations split 60/40 into train and test.

Evaluation results

17 evaluations · 17 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: 1-NN on GenePT embeddings (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
2.98% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

1-NN on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row '1-NN', column 'HepG2'
Configuration: Weighted 10-NN on GenePT embeddings (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
0.86% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

10-NN on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row '10-NN', column 'HepG2'
Configuration: Per-gene L2 logistic regression on GenePT embeddings (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
12.9% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Logistic regression on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'Logistic regression', column 'HepG2'
Configuration: Perturbation majority vote (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
0% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Majority vote on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'Majority vote', column 'HepG2'
Configuration: Scouter (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
55.1% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Scouter on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'Scouter', column 'HepG2'
Configuration: scVI perturbation model, mean output (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
67% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scVI mean on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'scVI mean', column 'HepG2'
Configuration: scVI perturbation model, sampled output (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
3.75% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scVI sampling on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'scVI sampling', column 'HepG2'
Configuration: VAE adapted from scGen (Sun et al. 2026)Protocol: Sun et al. 2026 unseen-perturbation DE classification (within cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
54.4% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

VAE scGen on Sun et al. 2026 within-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-within-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 1, row 'VAE scGen', column 'HepG2'
Configuration: 1-NN on GenePT embeddings (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
2.76% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

1-NN on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row '1-NN', column 'HepG2'
Configuration: Weighted 10-NN on GenePT embeddings (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
0.47% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

10-NN on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row '10-NN', column 'HepG2'
Configuration: Per-gene L2 logistic regression on GenePT embeddings (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
18.9% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Logistic regression on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'Logistic regression', column 'HepG2'
Configuration: Perturbation majority vote (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
0% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Majority vote on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'Majority vote', column 'HepG2'
Configuration: scVI perturbation model, mean output (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
81.2% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scVI mean on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'scVI mean', column 'HepG2'
Configuration: scVI perturbation model, sampled output (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
33.4% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scVI sampling on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'scVI sampling', column 'HepG2'
Configuration: STATE (few-shot cross-cell-line) (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
2.68% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

STATE on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'STATE', column 'HepG2'
Configuration: TranScouter (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
62.1% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

TranScouter on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'TranScouter', column 'HepG2'
Configuration: VAE adapted from scGen (Sun et al. 2026)Protocol: Sun et al. 2026 cellular-context DE classification (cross cell line)
Dataset subset: HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
62.6% Proportion (share of perturbation-gene pairs predicted as differentially expressed (compare with the printed true DE prevalence))
percent · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

VAE scGen on Sun et al. 2026 cross-cell-line DE classification, HepG2

lit-cells-networks-20261011-sun2026de-protocol-cross-cell-line

Aggregation: Not reported

Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models · Table 3, row 'VAE scGen', column 'HepG2'

Source checking is not independent reproduction. Release 2026-10-23-5347695500ed.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-23-5347695500ed · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Subset and evaluation context

This record describes a particular subset or cohort used in an evaluation. Its results do not describe the full dataset.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

5 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-23-5347695500ed
Property and statementOriginal source and locationReview and provenance
Source dataset label
HepG2
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Sections 3.1-3.2; Table 5

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.source_dataset_label

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Source location
Sections 3.1-3.2; Table 5
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Sections 3.1-3.2; Table 5

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.source_locator

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Split
60% train / 40% test perturbations
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Sections 3.1-3.2; Table 5

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.split

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Description
HepG2 essential-gene screen, normalised to 10,000 counts and log1p; perturbations split 60/40 into train and test.
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Sections 3.1-3.2; Table 5

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: description

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Name
HepG2 essential-gene Perturb-seq, 40% test perturbations (Sun et al. 2026)
Context-only references
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models

Original source ↗

Sections 3.1-3.2; Table 5

Version: bioRxiv preprint version 1, posted 2026-07-24
Retrieved: 2026-10-11T21:35:10Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: name

Source artifact SHA-256: fa1c6a6345c45e14b9c373dfa8aff12633ae646feece1cfa3899c3ed61f6cfdf

Hash scope: Exact bytes of one download; bioRxiv serves slightly different PDF bytes per download, so the gzip copy in artifacts/ is the reference.

Inspected artifact

Sources and history

Release 2026-10-23-5347695500ed · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-cells-networks-20261011-sun2026de-data-hepg2

areas
single-cell
contexts
research
split
60% train / 40% test perturbations
source dataset label
HepG2
source locator
Sections 3.1-3.2; Table 5
missing metadata
version: reason: unreported
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