| Configuration: AlphaFold 3 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.91 lddt-lp fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand af3 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-LP row, AlphaFold 3 column; Table 1 assessable count |
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| Configuration: AlphaFold 3 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.77 lddt-pli fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand af3 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-PLI row, AlphaFold 3 column; Table 1 assessable count |
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| Configuration: AlphaFold 3 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 64.9% success-rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand af3 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, Success rate row, AlphaFold 3 column; Table 1 assessable count |
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| Configuration: Boltz-1 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.89 lddt-lp fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand boltz1 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-LP row, Boltz-1 column; Table 1 assessable count |
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| Configuration: Boltz-1 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.71 lddt-pli fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand boltz1 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-PLI row, Boltz-1 column; Table 1 assessable count |
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| Configuration: Boltz-1 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 55% success-rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand boltz1 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, Success rate row, Boltz-1 column; Table 1 assessable count |
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| Configuration: Chai-1 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.89 lddt-lp fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand chai1 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-LP row, Chai-1 column; Table 1 assessable count |
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| Configuration: Chai-1 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.7 lddt-pli fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand chai1 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-PLI row, Chai-1 column; Table 1 assessable count |
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| Configuration: Chai-1 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 51.2% success-rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand chai1 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, Success rate row, Chai-1 column; Table 1 assessable count |
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| Configuration: HelixFold 3 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.89 lddt-lp fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand helixfold3 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-LP row, HelixFold 3 column; Table 1 assessable count |
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| Configuration: HelixFold 3 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.69 lddt-pli fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand helixfold3 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-PLI row, HelixFold 3 column; Table 1 assessable count |
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| Configuration: HelixFold 3 — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 51.8% success-rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand helixfold3 Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, Success rate row, HelixFold 3 column; Table 1 assessable count |
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| Configuration: Protenix — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.89 lddt-lp fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand protenix Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-LP row, Protenix column; Table 1 assessable count |
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| Configuration: Protenix — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 0.7 lddt-pli fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand protenix Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, LDDT-PLI row, Protenix column; Table 1 assessable count |
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| Configuration: Protenix — FoldBench published inference | Protocol: FoldBench protein-ligand published full-set assessment Dataset: FoldBench protein-ligand published targets | 50.7% success-rate percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcefoldbench protein ligand protenix Not reported Aggregation: source table mean FoldBench supplementary target coverage and performance · Supplementary Table 3, protein-ligand block, Success rate row, Protenix column; Table 1 assessable count |
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