Prospective research and clinical programme after earlier unresolved testing; 29 staggered monthly cycles, each cohort at least three.
These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.
Release 2026-09-30-e37e3ab1284d · Evidence verified: Not verified
Exact outcomes, predictions, identifiers and evaluator are connected.
Missing or unresolved evidence
Verified: Not verified
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Missing or unresolved evidence
Verified: Not verified
A pinned recipe describes the inputs, environment and resource requirements.
Missing or unresolved evidence
Verified: Not verified
Separate data and exposure records support an independent test.
Missing or unresolved evidence
Verified: Not verified
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1 evaluation · 14 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 5.1% additional_diagnostic_yield percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Review of Talos output |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 221 first_cycle_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 92% first_cycle_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 109 improved_analysis_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 45% improved_analysis_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 20 later_cycle_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 8% later_cycle_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 5 new_candidates_per_1000 variants per 1000 cases per cycle · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning During iterative reanalysis |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 241 new_confirmed_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Review of Talos output |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 78 new_gene_disease_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 32% new_gene_disease_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 54 new_variant_evidence_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 22% new_variant_evidence_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half |
| Configuration: Talos monthly iterative reanalysis with clinical confirmation | Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals | 238 newly_diagnosed_individuals count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceTalos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Review of Talos output |
Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.
A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.eligible_individuals 4735 Context-only references | Automated reanalysis of genomic data for rare disease diagnostics at scale No field-specific location recorded Version: Nature Medicine 2026 final publication, 24 June 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.initial_test_years 2017–2022 Context-only references | Automated reanalysis of genomic data for rare disease diagnostics at scale No field-specific location recorded Version: Nature Medicine 2026 final publication, 24 June 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.private_data_not_included true Context-only references | Automated reanalysis of genomic data for rare disease diagnostics at scale No field-specific location recorded Version: Nature Medicine 2026 final publication, 24 June 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.reanalysis_period 2023–2025 Context-only references | Automated reanalysis of genomic data for rare disease diagnostics at scale No field-specific location recorded Version: Nature Medicine 2026 final publication, 24 June 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| description Prospective research and clinical programme after earlier unresolved testing; 29 staggered monthly cycles, each cohort at least three. Context-only references | Automated reanalysis of genomic data for rare disease diagnostics at scale No field-specific location recorded Version: Nature Medicine 2026 final publication, 24 June 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| name Talos 4,735 unresolved individuals Context-only references | Automated reanalysis of genomic data for rare disease diagnostics at scale No field-specific location recorded Version: Nature Medicine 2026 final publication, 24 June 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
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Release 2026-09-30-e37e3ab1284d · Record review: source checked
Stable ID: uc-clinical-20260930-reanalysis-4735-data