Configuration

Talos monthly iterative reanalysis with clinical confirmation

New evidence flags, monthly PanelApp/ClinVar updates and accredited-laboratory classification; all reported study settings.

1 evaluation · 14 results

Overview

New evidence flags, monthly PanelApp/ClinVar updates and accredited-laboratory classification; all reported study settings.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

1 evaluation · 14 results. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	5.1% additional_diagnostic_yield percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Review of Talos output
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	221 first_cycle_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	92% first_cycle_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	109 improved_analysis_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	45% improved_analysis_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	20 later_cycle_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	8% later_cycle_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Twenty-nine cycles
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	5 new_candidates_per_1000 variants per 1000 cases per cycle · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning During iterative reanalysis
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	241 new_confirmed_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Review of Talos output
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	78 new_gene_disease_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	32% new_gene_disease_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	54 new_variant_evidence_diagnoses count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	22% new_variant_evidence_share percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning More than half
Configuration: Talos monthly iterative reanalysis with clinical confirmation	Protocol: Talos programme reanalysis yield Dataset: Talos 4,735 unresolved individuals	238 newly_diagnosed_individuals count · unknown Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Talos monthly reanalysis programme Not reported Aggregation: Not reported Automated reanalysis of genomic data for rare disease diagnostics at scale · Results, Iterative reanalysis, paragraph beginning Review of Talos output

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

Use this model

How it works, versions and access

Related profile: Talos. This page retains the exact record and its evaluation context.

Strengths, limitations and unresolved questions

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-30-e37e3ab1284d
Property and statement	Original source and location	Review and provenance
Relationship: variant of uc-clinical-20260930-method-talos Individual claims	Automated reanalysis of genomic data for rare disease diagnostics at scale Original source ↗ Results and Methods; Talos workflow Version: Nature Medicine 2026 final publication, 24 June 2026 Retrieved: 2026-09-30T21:24:16Z	source checked automated source review · 2026-09-30 Audit details Transcription from inspected primary source. No execution, independent replication or human scientific review. Field: `links:variant_of:uc-clinical-20260930-method-talos` Claim: uc-clinical-20260930-association-talos-monthly Source artifact SHA-256: `629b9578ac42717245256feca69dc9c9d5442deb7d282dd1bdc5a6c1a1efd2ec` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

All evidence (CSV)All evidence (JSONL)How to read the evidence

Sources and history

View linked audit checks and correction history

Release 2026-09-30-e37e3ab1284d · Record review: source checked

1 source records and release history

Automated reanalysis of genomic data for rare disease diagnostics at scale · Original source · Nature Medicine 2026 final publication, 24 June 2026

Download this release

Technical metadata and extraction receipts

Stable ID: uc-clinical-20260930-talos-monthly

areas: dna-genomes
contexts: clinical_research
review: method: automated_source_review; reviewer: Codex clinical coverage worker; date: 2026-09-30; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20260930-source-talos
missing metadata: software commit: not extracted; per cycle annotation snapshots: not extracted
parent identity review: source id: uc-clinical-20260930-source-talos; source locator: Results and Methods; Talos workflow; method: automated_source_review

Related records

variant of: Talos
subject: Configuration identity: Talos monthly iterative reanalysis with clinical confirmation
configuration: Talos monthly reanalysis programme

Suggest a correction