Tumour necrosis factor alpha as the design target for the AlphaProteo binder design campaign, with the input structure and hotspot residues given in Table S1.
3 evaluations · 3 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: AlphaProteo v1 | Protocol: AlphaProteo yeast-display binding screen, hit at binding signal above 0.2 Dataset: AlphaProteo binder design target TNF-alpha | 0% Hit rate (yeast-display binding signal above 0.2, over designs tested) percent · higher Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAlphaProteo v1 on TNF-alpha (yeast-display hit rate, Table S2) uc-binder-20261022-protocol-alphaproteo-yeast-display-signal-0-2 Aggregation: Not reported De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table S2, 'Success (%)' block, row 'AlphaProteo v1', column 'TNF-alpha' |
| Configuration: AlphaProteo v2 | Protocol: AlphaProteo yeast-display binding screen, hit at binding signal above 0.2 Dataset: AlphaProteo binder design target TNF-alpha | 0% Hit rate (yeast-display binding signal above 0.2, over designs tested) percent · higher Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAlphaProteo v2 on TNF-alpha (yeast-display hit rate, Table S2) uc-binder-20261022-protocol-alphaproteo-yeast-display-signal-0-2 Aggregation: Not reported De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table S2, 'Success (%)' block, row 'AlphaProteo v2', column 'TNF-alpha' |
| Configuration: AlphaProteo, pooled over tested design systems | Protocol: AlphaProteo yeast-display binding screen, hit at binding signal above 0.2 Dataset: AlphaProteo binder design target TNF-alpha | 0% Hit rate (yeast-display binding signal above 0.2, over designs tested; pooled over the AlphaProteo design systems tested for this target) percent · higher Uncertainty: Not reported by the source: No interval or replicate count is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceAlphaProteo on TNF-alpha, pooled over tested design systems (yeast-display hit rate, Table 1) uc-binder-20261022-protocol-alphaproteo-yeast-display-signal-0-2 Aggregation: Not reported De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table 1, 'Experimental success rate (%)' block, row 'AlphaProteo', column 'TNF-alpha' |
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7 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Assay Yeast surface display with flow cytometry; HTRF for KD of expressed hits Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Population Binder designs generated against TNF-alpha, 50 to 140 amino acids long Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Reported name TNF-alpha Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Source location Table 1, column 'TNF-alpha'; Table S1 Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Version arXiv:2409.08022v1 Table S1 Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Description Tumour necrosis factor alpha as the design target for the AlphaProteo binder design campaign, with the input structure and hotspot residues given in Table S1. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Name AlphaProteo binder design target TNF-alpha Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table 1, column 'TNF-alpha'; Table S1 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-data-alphaproteo-tnfa