| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.77 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D4; ID 'SRR11012403'; Software 'Parabricks'; column 'Cost ($)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:12:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C4; ID 'SRR11012403'; Software 'Parabricks'; column 'Runtime (h/m/s)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.71 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D6; ID 'SRR11012404'; Software 'Parabricks'; column 'Cost ($)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:12:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C6; ID 'SRR11012404'; Software 'Parabricks'; column 'Runtime (h/m/s)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.74 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D8; ID 'SRR11012405'; Software 'Parabricks'; column 'Cost ($)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:12:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C8; ID 'SRR11012405'; Software 'Parabricks'; column 'Runtime (h/m/s)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.74 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D10; ID 'SRR11012406'; Software 'Parabricks'; column 'Cost ($)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:10:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C10; ID 'SRR11012406'; Software 'Parabricks'; column 'Runtime (h/m/s)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.93 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D12; ID 'SRR11012408'; Software 'Parabricks'; column 'Cost ($)' |
|---|
| Configuration: NVIDIA Parabricks Germline v4.0.1-1 on a GCP VM with 48 vCPUs, 58 GB memory and 1 T4 GPU (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:14:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceParabricks on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C12; ID 'SRR11012408'; Software 'Parabricks'; column 'Runtime (h/m/s)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.82 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D3; ID 'SRR11012403'; Software 'Sentieon'; column 'Cost ($)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:14:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C3; ID 'SRR11012403'; Software 'Sentieon'; column 'Runtime (h/m/s)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.95 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D5; ID 'SRR11012404'; Software 'Sentieon'; column 'Cost ($)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:15:03 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C5; ID 'SRR11012404'; Software 'Sentieon'; column 'Runtime (h/m/s)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 1.03 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D7; ID 'SRR11012405'; Software 'Sentieon'; column 'Cost ($)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:15:38 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C7; ID 'SRR11012405'; Software 'Sentieon'; column 'Runtime (h/m/s)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.97 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D9; ID 'SRR11012406'; Software 'Sentieon'; column 'Cost ($)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:14:48 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C9; ID 'SRR11012406'; Software 'Sentieon'; column 'Runtime (h/m/s)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0.96 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D11; ID 'SRR11012408'; Software 'Sentieon'; column 'Cost ($)' |
|---|
| Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025) | Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study | 0:16:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C11; ID 'SRR11012408'; Software 'Sentieon'; column 'Runtime (h/m/s)' |
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