Configuration

Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)

Sentieon rows of Table S2.

Overview

Sentieon rows of Table S2.

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Evaluations and results

2 evaluations · 19 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	10 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D13; ID 'ERR1955532'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	10.7 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D15; ID 'ERR1955536'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	3:00:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C15; ID 'ERR1955536'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	9.76 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D17; ID 'ERR1955539'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	3:45:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C17; ID 'ERR1955539'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	8.02 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D19; ID 'ERR1955540'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	3:02:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C19; ID 'ERR1955540'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	9.44 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D21; ID 'ERR1955541'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WGS FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WGS samples from Illumina's Polaris project (HiSeq X, 150 bp reads)	3:50:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WGS samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wgs-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C21; ID 'ERR1955541'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0.82 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D3; ID 'SRR11012403'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0:14:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C3; ID 'SRR11012403'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0.95 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D5; ID 'SRR11012404'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0:15:03 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C5; ID 'SRR11012404'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	1.03 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D7; ID 'SRR11012405'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0:15:38 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C7; ID 'SRR11012405'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0.97 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D9; ID 'SRR11012406'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0:14:48 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C9; ID 'SRR11012406'; Software 'Sentieon'; column 'Runtime (h/m/s)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0.96 compute-cost us-dollar · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), D11; ID 'SRR11012408'; Software 'Sentieon'; column 'Cost ($)'
Configuration: Sentieon DNASeq v202308 on a GCP VM with 64 vCPUs and 57 GB memory (Franzoso et al. 2025)	Protocol: WES FASTQ-to-VCF runtime and cost on GCP, Sentieon versus Parabricks (Franzoso et al. 2025 Table S2) Dataset: Five WES samples (Twist Core Exome, Illumina NextSeq 500, 2x75 bp) from an HLH-like syndrome study	0:16:00 runtime second · lower Uncertainty: Not reported by the source: Single run per cell Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Sentieon on GCP, WES samples (Franzoso et al. 2025) model-execution-20261009-protocol-franzoso2025-wes-gcp Aggregation: Not reported Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial; Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Table S2 (CTS-18-e70416-s002.xlsx), C11; ID 'SRR11012408'; Software 'Sentieon'; column 'Runtime (h/m/s)'

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Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

2 source records and release history

Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial · Original source · Clinical and Translational Science 18(11):e70416, published 2025-11-18; PMC12627752 full-text XML
Franzoso et al. 2025, Table S2 (runtime and costs per sample) and Table S1 (sample identifiers) · Original source · CTS-18-e70416-s002.xlsx (Table S2) inside the Europe PMC supplementary files bundle for PMC12627752

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Technical metadata and extraction receipts

Stable ID: model-execution-20261009-config-franzoso2025-sentieon-dnaseq-202308-gcp-64vcpu

areas: dna-genomes
contexts: clinical_research
method types: conventional_pipeline
foundation model eligible: false
reported name: Sentieon
version: v202308
hardware: description: 64 vCPUs, 57 GB memory, no GPU; baseline cost 1.79 USD per hour
protocol: Default parameters and steps: alignment, duplicate marking, base recalibration and variant calling, FASTQ to VCF
source locator: Methods 'Design of the Benchmark' paragraph 1 and 'Cloud Deployment Design and Implementation' paragraph 3

Related records

configuration of: Sentieon DNASeq
system: Sentieon on GCP, WES samples (Franzoso et al. 2025)
system: Sentieon on GCP, WGS samples (Franzoso et al. 2025)

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