N4-methylcytosine (4mC) site detection benchmark, C. elegans set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); as used in Feng et al. 2025 Table 3.
5 evaluations · 5 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Caduceus-Ph (C.Elegans 4mC classification) | Protocol: Feng C.Elegans 4mC sequence classification Dataset: Feng C.Elegans 4mC dataset | 0.596 AUROC (task: c.elegans 4mc) unitless · higher Uncertainty: Not reported by the source: Table 3 prints point AUCs only. Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceCaduceus-Ph C.Elegans 4mC evaluation Table 3, frozen embeddings + task-specific random forest classifier Aggregation: Not reported Benchmarking DNA foundation models for genomic and genetic tasks · Table 3, row 'C.Elegans 4mC', column 'Caduceus-Ph'. |
| Configuration: DNABERT-2 (C.Elegans 4mC classification) | Protocol: Feng C.Elegans 4mC sequence classification Dataset: Feng C.Elegans 4mC dataset | 0.599 AUROC (task: c.elegans 4mc) unitless · higher Uncertainty: Not reported by the source: Table 3 prints point AUCs only. Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceDNABERT-2 C.Elegans 4mC evaluation Table 3, frozen embeddings + task-specific random forest classifier Aggregation: Not reported Benchmarking DNA foundation models for genomic and genetic tasks · Table 3, row 'C.Elegans 4mC', column 'DNABERT-2'. |
| Configuration: GROVER (C.Elegans 4mC classification) | Protocol: Feng C.Elegans 4mC sequence classification Dataset: Feng C.Elegans 4mC dataset | 0.606 AUROC (task: c.elegans 4mc) unitless · higher Uncertainty: Not reported by the source: Table 3 prints point AUCs only. Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGROVER C.Elegans 4mC evaluation Table 3, frozen embeddings + task-specific random forest classifier Aggregation: Not reported Benchmarking DNA foundation models for genomic and genetic tasks · Table 3, row 'C.Elegans 4mC', column 'GROVER'. Printed in bold (table footnote: 'Bolded: higher than at least two other AUCs, p < 0.01.'). |
| Configuration: HyenaDNA (C.Elegans 4mC classification) | Protocol: Feng C.Elegans 4mC sequence classification Dataset: Feng C.Elegans 4mC dataset | 0.596 AUROC (task: c.elegans 4mc) unitless · higher Uncertainty: Not reported by the source: Table 3 prints point AUCs only. Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceHyenaDNA C.Elegans 4mC evaluation Table 3, frozen embeddings + task-specific random forest classifier Aggregation: Not reported Benchmarking DNA foundation models for genomic and genetic tasks · Table 3, row 'C.Elegans 4mC', column 'HyenaDNA'. |
| Configuration: NT-v2 (C.Elegans 4mC classification) | Protocol: Feng C.Elegans 4mC sequence classification Dataset: Feng C.Elegans 4mC dataset | 0.649 AUROC (task: c.elegans 4mc) unitless · higher Uncertainty: Not reported by the source: Table 3 prints point AUCs only. Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceNT-v2 C.Elegans 4mC evaluation Table 3, frozen embeddings + task-specific random forest classifier Aggregation: Not reported Benchmarking DNA foundation models for genomic and genetic tasks · Table 3, row 'C.Elegans 4mC', column 'NT-v2'. Printed in bold (table footnote: 'Bolded: higher than at least two other AUCs, p < 0.01.'). |
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33 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Negatives 60662 Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PMC12663285.1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. |
| Negatives 60662 Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks: Supplementary Data 1-6 Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature Communications 16, 10780 (2025); Supplementary Data 1-6 workbook (MOESM3, .xlsm) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Negatives 60662 Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks: Supplementary Information Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature Communications 16, 10780 (2025); Supplementary Information PDF (MOESM1, 11 pages) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Population N4-methylcytosine (4mC) site detection benchmark, C. elegans set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); sequence length median 41 bp (range 41-41 bp) per Supplementary Data 6. Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PMC12663285.1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. |
| Population N4-methylcytosine (4mC) site detection benchmark, C. elegans set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); sequence length median 41 bp (range 41-41 bp) per Supplementary Data 6. Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks: Supplementary Data 1-6 Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature Communications 16, 10780 (2025); Supplementary Data 1-6 workbook (MOESM3, .xlsm) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Population N4-methylcytosine (4mC) site detection benchmark, C. elegans set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); sequence length median 41 bp (range 41-41 bp) per Supplementary Data 6. Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks: Supplementary Information Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature Communications 16, 10780 (2025); Supplementary Information PDF (MOESM1, 11 pages) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Positives 60662 Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PMC12663285.1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. |
| Positives 60662 Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks: Supplementary Data 1-6 Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature Communications 16, 10780 (2025); Supplementary Data 1-6 workbook (MOESM3, .xlsm) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Positives 60662 Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks: Supplementary Information Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature Communications 16, 10780 (2025); Supplementary Information PDF (MOESM1, 11 pages) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scope note Methods ('Sequence classification datasets') state that for eukaryotic species 4mC site annotations often rely on computational predictions rather than direct genome-wide chemical mapping; Results treat these tasks as exploratory. Supplementary Note 2 (Supplementary Information pages 3-4) nonetheless marks this dataset 'Yes' for reliance on experimental evidence or gold-standard sources. Methods ('Sequence classification datasets', the paragraph defining four task categories) give 4mC site detection as an example of a human epigenetic task, but all six 4mC datasets are non-human (Table 3; Methods, 4mC paragraph). This dataset is recorded under its printed species. Context-only references | Benchmarking DNA foundation models for genomic and genetic tasks Supplementary Data 6, row 'C.elegans 4mC'; Supplementary Note 1 (Supplementary Information pages 1-2) Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PMC12663285.1 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. |
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
Stable ID: feng-dna-fm-20261014-dataset-t3-c-elegans-4mc