Configuration

ESM-C (300M) [ProteinGym 144fe22b snapshot]

ESM C learns protein sequence representations for downstream analysis.

Sources (5)

evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md

2 evaluations · 19 results

How it worksESMC workflow

Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.

Sources (5)

Overview

Model type

Protein representation transformer

Inputs

Protein amino-acid sequences.

Outputs

Final-layer or all-layer protein representations and masked-token outputs.

Access

Official project documentation and implementation: https://github.com/evolutionaryscale/esm

Sources (5)

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

2 evaluations · 19 results. Different protocols are not a single leaderboard.

Sorted by Spearman (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Spearman	Spearman (ProteinGym zero-shot DMS substitutions, Activity assays: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Binding assays: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Expression assays: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, High MSA depth proteins: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Human proteins: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Low MSA depth proteins: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, mean over selection types of the per-type mean over proteins of assay-level Spearman (all 217 assays))	Spearman (ProteinGym zero-shot DMS substitutions, Medium MSA depth proteins: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Organismal fitness assays: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Other eukaryote proteins: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Prokaryote proteins: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Stability assays: mean over proteins of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, variants with 1 substitution: mean over protein and selection-type groups of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, variants with 2 substitutions: mean over protein and selection-type groups of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, variants with 3 substitutions: mean over protein and selection-type groups of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, variants with 4 substitutions: mean over protein and selection-type groups of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, variants with 5 or more substitutions: mean over protein and selection-type groups of assay-level Spearman)	Spearman (ProteinGym zero-shot DMS substitutions, Virus proteins: mean over proteins of assay-level Spearman)
ESM-C (300M) [ProteinGym 144fe22b snapshot]Evaluation	ProteinGym AMFR official zero-shot Spearman snapshot, ProteinGym AMFR 4G3O official snapshot cohort	0.364	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
ESM-C (300M) [ProteinGym 144fe22b snapshot]Evaluation	ProteinGym v1.3 zero-shot DMS substitutions, ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	Not reported	0.423	0.315	0.408	0.52	0.468	0.337	0.406	0.399	0.36	0.481	0.441	0.526	0.415	0.258	0.191	0.155	0.217	0.242

All 19 result rows with coverage, uncertainty and sources

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym AMFR official zero-shot Spearman snapshot Dataset subset: ProteinGym AMFR 4G3O official snapshot cohort	0.364 Spearman unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M) AMFR official snapshot Not reported Aggregation: Not reported ProteinGym AMFR assay-level Spearman comparison · DMS_substitutions_Spearman_DMS_level.csv line 15, DMS ID=AMFR_HUMAN_Tsuboyama_2023_4G3O, column=ESM-C (300M)
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.406 Spearman (ProteinGym zero-shot DMS substitutions, mean over selection types of the per-type mean over proteins of assay-level Spearman (all 217 assays)) unitless · higher Uncertainty: SE 0.013. From compute_bootstrap_standard_error_functional_categories in performance_DMS_benchmarks.py at 144fe22 (default 10,000 resamples, lines 95-111 and 310-315); not an absolute standard error of the model's own average. Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Average_Spearman'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.415 Spearman (ProteinGym zero-shot DMS substitutions, variants with 1 substitution: mean over protein and selection-type groups of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Depth_1'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.258 Spearman (ProteinGym zero-shot DMS substitutions, variants with 2 substitutions: mean over protein and selection-type groups of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Depth_2'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.191 Spearman (ProteinGym zero-shot DMS substitutions, variants with 3 substitutions: mean over protein and selection-type groups of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Depth_3'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.155 Spearman (ProteinGym zero-shot DMS substitutions, variants with 4 substitutions: mean over protein and selection-type groups of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Depth_4'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.217 Spearman (ProteinGym zero-shot DMS substitutions, variants with 5 or more substitutions: mean over protein and selection-type groups of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Depth_5+'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.423 Spearman (ProteinGym zero-shot DMS substitutions, Activity assays: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Function_Activity'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.315 Spearman (ProteinGym zero-shot DMS substitutions, Binding assays: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Function_Binding'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.408 Spearman (ProteinGym zero-shot DMS substitutions, Expression assays: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Function_Expression'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.36 Spearman (ProteinGym zero-shot DMS substitutions, Organismal fitness assays: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Function_OrganismalFitness'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.526 Spearman (ProteinGym zero-shot DMS substitutions, Stability assays: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Function_Stability'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.52 Spearman (ProteinGym zero-shot DMS substitutions, High MSA depth proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'High_MSA_depth'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.337 Spearman (ProteinGym zero-shot DMS substitutions, Low MSA depth proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Low_MSA_depth'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.399 Spearman (ProteinGym zero-shot DMS substitutions, Medium MSA depth proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Medium_MSA_depth'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.468 Spearman (ProteinGym zero-shot DMS substitutions, Human proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Taxa_Human'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.481 Spearman (ProteinGym zero-shot DMS substitutions, Other eukaryote proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Taxa_Other_Eukaryote'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.441 Spearman (ProteinGym zero-shot DMS substitutions, Prokaryote proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Taxa_Prokaryote'
Configuration: ESM-C (300M) [ProteinGym 144fe22b snapshot]	Protocol: ProteinGym v1.3 zero-shot DMS substitutions Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)	0.242 Spearman (ProteinGym zero-shot DMS substitutions, Virus proteins: mean over proteins of assay-level Spearman) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Evaluation origin not reported · Source checked Methods, coverage and source ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22) ProteinGym zero-shot DMS substitutions, Spearman summary Aggregation: Not reported ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 50, row 'ESM-C (300M)', column 'Taxa_Virus'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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How it works, versions and access

Related profile: ESMC. This page retains the exact record and its evaluation context.

This configuration

ESM-C (300M), from the ProteinGym reference scores at commit 144fe22b.

record: ESM-C (300M) [ProteinGym 144fe22b snapshot]
configuration: 144fe22b07dfaeec2b366f2346203a9838a55b4c
entity type: Configuration

How it works

Pre-normalized transformer with rotary embeddings, SwiGLU feed-forward activations and no linear/layer-norm biases. The documented inputs are protein amino-acid sequences. The output consists of final-layer or all-layer protein representations and masked-token outputs.

Sources (5)

Versions and reproducibility

esmc-600m-2024-12 API identifier and biohub/ESMC-6B local example. The card specifies a2,048-token window after an initial 512-token training phase.

Sources (5)

Strengths, limitations and unresolved questions

Strengths and limitations

Strengths and considerations

The implementation supports local inference and a hosted interface, with downloadable model variants.
Sources (5)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md

Limitations and conditions

Hosted API names and downloadable weights identify different versions. The main repository does not by itself provide a complete per-checkpoint training manifest.
Sources (5)
evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md

Profile review details

Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied.

Stable record: discovery-model-esmc

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
Property	Description and evidence
Model type	Protein representation transformer Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Architecture	Pre-normalized transformer with rotary embeddings, SwiGLU feed-forward activations and no linear/layer-norm biases. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Inputs	Protein amino-acid sequences. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Outputs	Final-layer or all-layer protein representations and masked-token outputs. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Parameters	300M/30 layers, 600M/36 layers and 6B/80 layers in the checked model card. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Known versions	esmc-600m-2024-12 API identifier and biohub/ESMC-6B local example. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Training data	UniRef, MGnify and JGI protein sequences clustered at 70% identity. The card distinguishes83M, 372M and 2B clusters respectively from the number of repeated training tokens. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Training cutoff	The official ESMC-6B card identifies UniRef, MGnify and JGI clusters and training stages, but does not give a latest-sequence date shared across those corpora. · Not reported in inspected sources Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Context limits	The card specifies a2,048-token window after an initial 512-token training phase. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Weights licence	MIT is declared alongside third-party notices in the checked6B card; THIRD_PARTY_NOTICE.md lists dependency licences. Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Access	Official project documentation and implementation: https://github.com/evolutionaryscale/esm Sources (5) evolutionaryscale/esm: README.md; evolutionaryscale/esm: _assets/ESM3_README.md; evolutionaryscale/esm: THIRD_PARTY_NOTICE.md; biohub/ESMC-6B: README.md; biohub/ESMC-6B: config.json · Official biohub/ESMC-6B card: Model Architecture, Parameters, Training Data, Training Procedure and Limitations; THIRD_PARTY_NOTICE.md
Code licence	MIT Sources evolutionaryscale/esm: LICENSE.md · LICENSE.md: licence text

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

2 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Facets: method types 1 values foundation_model Individual claims	ProteinGym AMFR assay-level Spearman comparison Original source ↗ Proposer's report, ProteinGym AMFR: protein language and structure-conditioned models fit foundation_model Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c Retrieved: 2026-09-30	conflicting claim ["automated-source-review"] · 2026-10-12 Audit details Correct the method type from none to foundation_model (use-case baseline review 2026-10-12, table 2). Not source-checked in the review; this comparison has no baseline row. Evidence from docs/reviews/use-cases/baselines-2026-10-12.md. Independent review 2026-10-12: approved. See docs/reviews/2026-10-12-method-type-corrections.md. Conflicting source claim: `"[\"foundation_model\"]"`. Claim record status: source_checked. Field: `facets.method_types` Claim: metadata-correction-tags-20261012-1b81edf163973c4a5513 Source artifact SHA-256: `f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Relationship: configuration of discovery-model-esmc Individual claims	ProteinGym AMFR assay-level Spearman comparison Original source ↗ Pinned ProteinGym Spearman CSV header: ESM-C (300M) Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c Retrieved: 2026-09-30	source checked ["automated-source-review"] · 2026-09-30T21:40:59.576893+00:00 Audit details Field: `links:configuration_of:discovery-model-esmc` Claim: uc20260930-config-family-c091d3c5673344ca Source artifact SHA-256: `f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

ProteinGym AMFR assay-level Spearman comparison · Original source · 144fe22b07dfaeec2b366f2346203a9838a55b4c

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Technical metadata and extraction receipts

Stable ID: uc20260930-proteingym-amfr-config-esm-c-300m

areas: proteins-complexes
method types: foundation_model
source locator: See linked evaluation and result locators
missing metadata: checkpoint hash: reason: unextracted
review: method: automated-source-review; reviewer: codex; reviewed at: 2026-09-30T21:40:59.576893+00:00; scope: Primary-source transcription and catalogue applicability audit; not human scientific review or independent experimental reproduction.; reviewer note: role: experimental use-case curation
reported name: ESM-C (300M)
version: 144fe22b07dfaeec2b366f2346203a9838a55b4c
provenance note: Exact official CSV source-label configuration; checkpoint and per-assay scoring details are not inferred from similarly named methods.

Related records

configuration of: ESMC
subject: ESM-C (300M) [ProteinGym 144fe22b snapshot]: facets.method_types
subject: ESM-C (300M) [ProteinGym 144fe22b snapshot] family identity
system: ESM-C (300M) AMFR official snapshot
system: ESM-C (300M): ProteinGym zero-shot DMS substitutions summary (144fe22)

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