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SpliceAI2 fine-tuned on SF3B1-mutant and wild-type uveal melanoma (Jaganathan et al. 2026)

SpliceAI2 fine-tuned on SF3B1-mutant and wild-type uveal melanoma: Mutant and wild-type conditions supplied as two 147-RBP expression vectors with identical DNA input; 18 SF3B1-mutant and 62 wild-type tumours.

1 evaluation · 1 result

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Configuration: SpliceAI2 fine-tuned on SF3B1-mutant and wild-type uveal melanoma (Jaganathan et al. 2026)Protocol: SF3B1-associated junction usage differences in uveal melanoma, held-out genes (SpliceAI2 paper, Pearson)
Dataset: TCGA uveal melanoma RNA-seq, SF3B1-mutant and wild-type (as used by Jaganathan et al. 2026)		0.49 Pearson (junctions with competing acceptor 10 to 30 nt, weak polypyrimidine tract and A-rich branch point; held-out genes)
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SpliceAI2 SF3B1 fine-tune on uveal melanoma junction usage differences

rna-splicing-20261013-spliceai2-protocol-uvm-sf3b1

Aggregation: Not reported

A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026) · Main 'Modeling tissue-specific splicing' paragraph 4 '(Pearson r = 0.49; Fig. 2d)'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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Stable ID: rna-splicing-20261013-spliceai2-config-spliceai2-sf3b1-uvm

areas
dna-genomes
contexts
research
method types
supervised_machine_learning
foundation model eligible
false
reported name
SpliceAI2 (SF3B1)
version
Tissue-specific framework fine-tuned on TCGA uveal melanoma RNA-seq
parameters
Mutant and wild-type conditions supplied as two 147-RBP expression vectors with identical DNA input; 18 SF3B1-mutant and 62 wild-type tumours
source locator
Main 'Modeling tissue-specific splicing' paragraph 4; Methods 'SF3B1-mutant uveal melanoma (UVM)'
missing metadata
checkpoint: reason: unreported; note: No released weights named.
provenance note
SpliceAI2 fine-tuned on SF3B1-mutant and wild-type uveal melanoma (Jaganathan et al. 2026), as evaluated in the SpliceAI2 paper.
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