Model type
Recurrent neural network; this record is the paper-specific evaluated configuration.
2OMe-LM predicts whether the central nucleotide of an RNA window carries a 2′-O-methylation modification.
Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.
Recurrent neural network; this record is the paper-specific evaluated configuration.
RNA sequence windows centred on candidate modification sites
Probability that the central site is 2′-O-methylated
Official study implementation and usage documentation: https://github.com/CSUBioGroup/2OMe-LM/blob/2e22439723777b5bacdce72cdcd7cfbde9e88cd1/README.md. This pinned documentation revision is not automatically the evaluated weight revision.
limited source coverage · Automated source review, 2026-09-16. All specifications and missing details
1 evaluation · 7 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites | 0.919 AUC fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1, 2OMe-LM row, AUC column |
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites |
0.929
AUPR fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1. (btaf417-T1), row 8 2OMe-LM, column 7: Human RNA 2OMe sites, five-fold cross-validation AUPR |
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites |
0.873
Precision fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1. (btaf417-T1), row 8 2OMe-LM, column 4: Human RNA 2OMe sites, five-fold cross-validation Precision |
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites |
0.846
ACC fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1. (btaf417-T1), row 8 2OMe-LM, column 2: Human RNA 2OMe sites, five-fold cross-validation ACC |
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites |
0.811
Recall fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1. (btaf417-T1), row 8 2OMe-LM, column 5: Human RNA 2OMe sites, five-fold cross-validation Recall |
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites |
0.695
MCC unitless · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1. (btaf417-T1), row 8 2OMe-LM, column 8: Human RNA 2OMe sites, five-fold cross-validation MCC |
| Configuration: 2OMe-LM | Protocol: Human RNA 2OMe sites, five-fold cross-validation (human RNA 2-prime-O-methylation site prediction) Dataset: human RNA 2OMe sites |
0.841
F1-score fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and source2OMe-LM: human RNA 2-prime-O-methylation site prediction 41-nt centred RNA windows; balanced 8,037 positive and 8,037 negative samples after 80% identity filtering, then 8:2 train/test division. Average of five validation folds of the training set. Aggregation: Not reported 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Table 1. (btaf417-T1), row 8 2OMe-LM, column 3: Human RNA 2OMe sites, five-fold cross-validation F1-score |
Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.
SpliceBERT embeddings pass through a dimensionality-reduction layer. A second branch encodes k-mers with word2vec and a bidirectional LSTM. Fused features enter an attention block and three fully connected layers for site classification.
The linked evaluation record identifies 2OMe-LM: human RNA 2-prime-O-methylation site prediction. Its dataset, split, adaptation and evidence origin remain attached to the reported results.
Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.
Stable record: reported-model-7f5b8234967c54Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Model type | Recurrent neural network; this record is the paper-specific evaluated configuration.Sources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) |
| Architecture / procedure | SpliceBERT embeddings pass through a dimensionality-reduction layer. A second branch encodes k-mers with word2vec and a bidirectional LSTM. Fused features enter an attention block and three fully connected layers for site classification.Sources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) |
| Biological inputs | RNA sequence windows centred on candidate modification sitesSources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · 3 Results/3.4 Motif analysis (paragraph 2); 4 Conclusion (paragraph 1) |
| Outputs | Probability that the central site is 2′-O-methylatedSources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3); 3 Results/3.5 Case study (paragraph 1) |
| Parameters | An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources. · Not reported in inspected sourcesSources (2)2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model; CSUBioGroup/2OMe-LM README.md · 2 Materials and methods/2.1 Datasets; 2 Materials and methods/2.2 Model architecture; 2 Materials and methods/2.2 Model architecture/2.2.1 Pretrained RNA language model; 2 Materials and methods/2.2 Model architecture/2.2.2 Word2vec embedding; 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction; 2 Materials and methods/2.3 Deep learning baseline models; 2 Materials and methods/2.4 Evaluation metrics; 2 Materials and methods/2.5 Implementation details; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision |
| Known versions / configuration | 2OMe-LM is the comparison-table label; that label does not specify an immutable weight revision. · Not reported in inspected sourcesSources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · Model identification in the comparison table and corresponding Methods; immutable checkpoint revision is not supplied by the table label. |
| Training data / fitting | 8,037 positive and 8,037 negative examples, with an 80:20 training/test partition; SpliceBERT provides separately pretrained sequence features.Sources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · 2 Materials and methods/2.1 Datasets (paragraph 2); 2 Materials and methods/2.1 Datasets (paragraph 1) |
| Context limits | SpliceBERT supports up to 1,024 nucleotides; that backbone limit is not an independently verified limit of the complete predictor.Sources2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model · 3 Results/3.3 Effectiveness of pre-trained RNA language model (paragraph 1); Table btaf417-T2 (paragraph 1) |
| Access | Official study implementation and usage documentation: https://github.com/CSUBioGroup/2OMe-LM/blob/2e22439723777b5bacdce72cdcd7cfbde9e88cd1/README.md. This pinned documentation revision is not automatically the evaluated weight revision.SourcesCSUBioGroup/2OMe-LM README.md · README.md; installation, model download and usage instructions |
| Code licence | No explicit code licence was established from the paper’s availability statement and inspected repository-root documentation. · Not reported in inspected sourcesSourcesCSUBioGroup/2OMe-LM README.md · README.md and repository-root licence-file search |
| Weights licence | The inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately. · Not reported in inspected sourcesSourcesCSUBioGroup/2OMe-LM README.md · README.md; checkpoint/access documentation and licence scope |
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
20 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Diagram caption Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings. Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Diagram steps
| 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Diagram title Evaluated procedure (conceptual) Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Model type Recurrent neural network; this record is the paper-specific evaluated configuration. Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Architecture / procedure SpliceBERT embeddings pass through a dimensionality-reduction layer. A second branch encodes k-mers with word2vec and a bidirectional LSTM. Fused features enter an attention block and three fully connected layers for site classification. Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.2 Model architecture (paragraph 1); 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Weights licence The inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately. Individual claims | CSUBioGroup/2OMe-LM README.md README.md; checkpoint/access documentation and licence scope Version: 2e22439723777b5bacdce72cdcd7cfbde9e88cd1 | unreported automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Biological inputs RNA sequence windows centred on candidate modification sites Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 3 Results/3.4 Motif analysis (paragraph 2); 4 Conclusion (paragraph 1) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Outputs Probability that the central site is 2′-O-methylated Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction (paragraph 3); 3 Results/3.5 Case study (paragraph 1) Version: journal full text in PMC | source checked automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Parameters An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources. Individual claims | 2OMe-LM: predicting 2′-O-methylation sites in human RNA using a pre-trained RNA language model 2 Materials and methods/2.1 Datasets; 2 Materials and methods/2.2 Model architecture; 2 Materials and methods/2.2 Model architecture/2.2.1 Pretrained RNA language model; 2 Materials and methods/2.2 Model architecture/2.2.2 Word2vec embedding; 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction; 2 Materials and methods/2.3 Deep learning baseline models; 2 Materials and methods/2.4 Evaluation metrics; 2 Materials and methods/2.5 Implementation details; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: journal full text in PMC | unreported automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Parameters An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources. Individual claims | CSUBioGroup/2OMe-LM README.md 2 Materials and methods/2.1 Datasets; 2 Materials and methods/2.2 Model architecture; 2 Materials and methods/2.2 Model architecture/2.2.1 Pretrained RNA language model; 2 Materials and methods/2.2 Model architecture/2.2.2 Word2vec embedding; 2 Materials and methods/2.2 Model architecture/2.2.3 Feature fusion and prediction; 2 Materials and methods/2.3 Deep learning baseline models; 2 Materials and methods/2.4 Evaluation metrics; 2 Materials and methods/2.5 Implementation details; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2e22439723777b5bacdce72cdcd7cfbde9e88cd1 | unreported automated source review · 2026-09-16 Audit detailsPrimary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
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Stable ID: reported-model-7f5b8234967c54